Molecular mechanisms of fever and endogenous antipyresis.
Molecular mechanisms of fever and endogenous antipyresis.
复制标题
发热和内源性解热的分子机制。
DOI：
10.1111/j.1749-6632.2000.tb05376.x
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发表时间：
2000
影响因子：
5.2
通讯作者：
Dokladny,K
中科院分区：
文献类型：
--
作者：
Kozak,W;Kluger,MJ;Tesfaigzi,J;Kozak,A;Mayfield,KP;Wachulec,M;Dokladny,K
摘要：本文综述了近年来内源性解热机制的研究进展。发烧是致热和低温细胞因子和激素之间平衡的结果。尽管有大量证据表明发烧是作为宿主的防御反应而进化的，但重要的是体温升高不要太高。在过去 25 年里，人们已经发现了许多限制体温升高的内源性冷冻剂或退热剂。这些包括 α-MSH、精氨酸加压素、糖皮质激素、TNF（在某些情况下）和 IL-10。最近，越来越多的证据表明，细胞色素 P-450 (P-450) 作为花生四烯酸代谢替代途径的一部分，在减少发烧和炎症方面发挥着重要作用。支持 P-450 在内源性解热和抗炎作用的证据包括：(1) P-450 诱导剂可降低发烧，(2) P-450 抑制剂可引起更大的发烧，(3) 和 P-450 花生四烯酸代谢物可降低发烧。
Abstract:This review summarizes recent studies on endogenous antipyretic mechanisms. Fever is the result of a balance between pyrogenic and cryogenic cytokines and hormones. Although there is considerable evidence that fever evolved as a host defense response, it is important that the rise in body temperature not be too high. Many endogenous cryogens or antipyretics that limit the rise in body temperature have been identified during the last 25 years. These include α‐MSH, arginine vasopressin, glucocorticoids, TNF (under certain circumstances), and IL‐10. Most recently, evidence has accumulated that cytochromeP‐450 (P‐450), part of the alternative pathway for arachidonic acid metabolism, plays an important role in reduction of fever and inflammation. Supporting a role forP‐450 in endogenous antipyresis and antiinflammation includes evidence that (1) inducers ofP‐450 reduce fever, (2) inhibitors ofP‐450 cause a larger fever, (3) andP‐450 arachidonic acid metabolites reduce fever.