Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent.
Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent.
复制标题
在动脉粥样硬化之前和开发过程中淋巴细胞募集到主动脉壁是部分依赖性L-选择蛋白。
DOI：
10.1084/jem.20052205
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发表时间：
2006-05-15
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动脉粥样硬化是一种大动脉炎性疾病。主动脉细胞悬液的流式细胞术显示，B和T淋巴细胞和一些巨噬细胞和树突状细胞已经存在于正常/非炎症小鼠血管外膜中。连续转移的淋巴细胞组成性地归巢到主动脉，并在转移后7天内驻留在外膜内。淋巴细胞进入正常/非炎症或动脉粥样硬化倾向的动脉瘤部分依赖于L-选择素。抗原活化的树突状细胞诱导增加T淋巴细胞增殖的主动脉内过继转移后72小时。在载脂蛋白E缺陷小鼠动脉粥样硬化进展过程中，巨噬细胞、T细胞和树突状细胞的总数显著增加，但B细胞没有显著增加。这种免疫细胞组成的改变伴随着动脉粥样硬化血管外膜中三级淋巴组织的形成。这些结果表明，淋巴细胞已经驻留在正常/noninflamed主动脉粥样硬化发病前作为组成性运输的结果。动脉粥样硬化诱导支持抗原呈递的巨噬细胞和树突状细胞的募集。
Atherosclerosis is an inflammatory disease of large arteries. Flow cytometry of aortic cell suspensions showed that B and T lymphocytes and some macrophages and dendritic cells are already present in the adventitia of normal/noninflamed mouse aortas. Adoptively transferred lymphocytes constitutively homed to the aorta and resided within the adventitia up to 7 d after transfer. Lymphocyte trafficking into normal/noninflamed or atherosclerosis-prone aortas was partially L-selectin dependent. Antigen-activated dendritic cells induced increased T lymphocyte proliferation within the aorta 72 h after adoptive transfer. During progression of atherosclerosis in apolipoprotein-E–deficient mice, the total number of macrophages, T cells, and dendritic cells, but not B cells, increased significantly. This alteration in immune cell composition was accompanied by the formation of tertiary lymphoid tissue in the adventitia of atherosclerotic aortas. These results demonstrate that lymphocytes already reside within the normal/noninflamed aorta before the onset atherosclerosis as a consequence of constitutive trafficking. Atherosclerosis induces the recruitment of macrophages and dendritic cells that support antigen presentation.