From CO2 to 4H-Quinolizin-4-ones: A One-Pot Multicomponent Approach via Ag2O/Cs2CO3 Orthogonal Tandem Catalysis
From CO2 to 4H-Quinolizin-4-ones: A One-Pot Multicomponent Approach via Ag2O/Cs2CO3 Orthogonal Tandem Catalysis
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从 CO2 到 4H-Quinolizin-4-ones：通过 Ag2O/Cs2CO3 正交串联催化的一锅多组分方法
DOI：
10.1021/acs.joc.8b01206
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发表时间：
2018-08-17
影响因子：
3.6
通讯作者：
Gong, Han-Yuan
中科院分区：
文献类型：
--
作者：
Dong, Chao-Chen;Xiang, Jun-Feng;Gong, Han-Yuan
使用二氧化碳作为 Cl 前驱体，我们在此报告了相对简单且经济有效的正交串联催化，即 Ag2O 与 Cs2CO3 结合，可促进多组分串联反应，形成两个新的 C-C 和一个新的 C-N 键。 4H-Quinolizin-4-ones 是多种生物活性分子的关键骨架成分，收率高达 99%。本方法具有广泛的底物范围和温和的反应条件，并受益于使用具有成本效益的反应和催化剂。
Using carbon dioxide as a Cl precursor, here we report relatively simple and cost-effective orthogonal tandem catalysis, namely Ag2O in conjunction with Cs2CO3 serves to promote a multi component tandem reaction forming two new C-C and one new C-N bonds. 4H-Quinolizin-4-ones, key skeletal components in a variety of biologically active molecules, were obtained with yields up to 99%. The present approach features a broad substrate scope and mild reaction conditions and benefits from using cost-effective reaction and catalysts.