Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
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DOI：
10.1126/science.1129139
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发表时间：
2006-09-29
期刊：
影响因子：
56.9
通讯作者：
Pages, Franck
中科院分区：
文献类型：
--
作者：
Galon, Jerom;Costes, Anne;Pages, Franck
获得性免疫反应在控制人类肿瘤生长和复发中的作用一直存在争议。我们通过基因表达谱和原位免疫组织化学染色表征了大量人类结直肠癌队列中的肿瘤浸润性免疫细胞。总的来说，免疫学数据(肿瘤样本中免疫细胞的类型、密度和位置)被发现比目前用于分期结直肠癌的组织病理学方法更能预测患者的生存。结果在另外两个患者群体中得到了验证。这些数据支持获得性免疫反应影响人类肿瘤行为的假设。因此，肿瘤浸润性免疫细胞的原位分析在结直肠癌和其他恶性肿瘤的治疗中可能是一种有价值的预后工具。
The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data ( the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.