Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model
Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model
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DOI：
10.1159/000471854
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发表时间：
2017-05
期刊：
影响因子：
5
通讯作者：
Isao Kawahara;Takuya Mori;Kei Goto;K. Fujii;H. Ohmori;Shingo Kishi;Rina Fujiwara-Tani;H. Kuniyasu-H.-Kuniya
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文献类型：
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作者：
Isao Kawahara;Takuya Mori;Kei Goto;K. Fujii;H. Ohmori;Shingo Kishi;Rina Fujiwara-Tani;H. Kuniyasu-H.-Kuniya
使用癌基质细胞评估2种类型的脂肪酸对结直肠癌（CRC）的潜在作用。亚油酸（LA; C-18，n-6不饱和脂肪酸）和反式油酸（EA; C-18，反式酸），两者都已知影响结肠癌发生和癌症进展，通过管饲法给予BALB/c小鼠，其背部接种有CT 26同源结肠癌细胞。EA和LA治疗均促进肿瘤生长和转移。EA和LA也增加了肿瘤包膜中CD 133阳性基质细胞的数量。重要的是，那些在肿瘤周围的癌细胞，物理上附着于CD 133阳性基质细胞，也表达CD 133。这些结果表明，EA和LA可能通过物理联系诱导癌细胞的干细胞性，并促进癌症转移。
The potential effects of 2 types of fatty acids on colorectal cancer (CRC) were assessed using cancer stromal cells. Linoleic acid (LA; C-18, n-6 unsaturated fatty acid) and elaidic acid (EA; C-18, trans acid), both known to affect colon carcinogenesis and cancer progression, were administered by gavage to BALB/c mice, which were inoculated with CT26 syngeneic colon cancer cells in the back. Both EA and LA treatments enhanced tumor growth and metastasis. EA and LA also increased the number of CD133-positive stromal cells in the tumor capsule. Importantly, those cancer cells at the tumor periphery, physically attached to CD133-positive stromal cells, also expressed CD133. These findings suggest that EA and LA might induce stemness in cancer cells through physical association and promote cancer metastasis.