Role of hormone-controlled Th1-and Th2-type cytokines in successful pregnancy
Role of hormone-controlled Th1-and Th2-type cytokines in successful pregnancy
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DOI：
10.1016/s0165-5728(00)00299-x
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发表时间：
2000-09-01
影响因子：
3.3
通讯作者：
Romagnani, S
中科院分区：
文献类型：
--
作者：
Piccinni, MP;Scaletti, C;Romagnani, S
CD 4+辅助性T（Th）细胞发育为1型（Th 1）或2型（Th 2）效应细胞，其特征在于其细胞因子产生的相反模式，可以受到包括激素在内的几种因素的影响。孕酮促进IL-4和IL-5的产生，而松弛素促进T细胞产生IFN-γ。白血病抑制因子（LIF），胚胎植入所必需的，是上调IL-4和孕酮。此外，蜕膜T细胞产生LIF和/或Th 2细胞因子有助于维持妊娠。我们的研究结果表明，松弛素和孕酮可能有助于调节免疫稳态在怀孕期间。(C)2000 Elsevier Science B. V.保留所有权利。
Development of CD4+ helper T (Th) cells into type 1 (Th1) or type 2 (Th2) effecters, as characterized by their opposite pattern of cytokine production, can be influenced by several factors, including hormones. Progesterone promotes the production of IL-4 and IL-5, whereas relaxin promotes the production of IFN-gamma by T cells. Leukemia inhibitory factor (LIF), essential for embryo implantation, is up-regulated by IL-4 and progesterone. Moreover, the production of LIF and/or Th2 cytokines by decidual T cells contributes to the maintenance of pregnancy. Our results suggest that relaxin and progesterone may contribute to the regulation of the immune homeostasis during pregnancy. (C) 2000 Elsevier Science B.V. All rights reserved.