The effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis A comparative study
The effect of stem cell therapy and comprehensive physical therapy in motor and non-motor symptoms in patients with multiple sclerosis A comparative study
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DOI：
10.1097/md.0000000000021646
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发表时间：
2020-08-21
期刊：
影响因子：
1.6
通讯作者：
Awidi, Abdalla
中科院分区：
文献类型：
--
作者：
Alghwiri, Alia A.;Jamali, Fatima;Awidi, Abdalla
简介：多发性硬化症（PwMS）患者会经历各种各样的残疾，这些残疾会对他们的生活质量（QOL）产生负面影响。药物治疗、物理治疗锻炼和干细胞治疗等干预措施已被用于改善PwMS患者的生活质量。然而，关于联合干预的益处的证据有限。本研究的目的是探讨物理治疗练习（PTE）和沃顿果冻间充质干细胞（WJ-MSCs）注射相结合对PwMS患者运动和非运动症状的影响。方法：60名PwMS将被分配到PTE， WJ-MSCs或联合组，随访12个月，并使用综合措施进行检查。PTE组的参与者将接受为期6个月的每周2次有监督的锻炼计划，然后是另外6个月的家庭锻炼计划。WJ-MSCs组将在前6个月内接受3次WJ-MSCs注射，然后鼓励他们遵循积极的生活方式。第三组将同时接受两种干预。讨论：这项研究将有助于更好地理解物理治疗和间充质干细胞治疗的联合作用。本研究的结果可能会减少残疾，改善PwMS患者的生活质量，从而降低全球范围内这些患者终生护理的相关成本。
Introduction: People with multiple sclerosis (PwMS) experience a wide range of disabilities which negatively impact their quality of life (QOL). Several interventions have been used in PwMS such as medication, physical therapy exercises and stem cell therapy to improve their QOL. However, there is a limited evidence on the benefits of combining interventions. The purpose of this study is to explore the effect of combining physical therapy exercises (PTE) and Wharton Jelly mesenchymal stem cell (WJ-MSCs) injections on motor and non-motor symptoms versus each intervention alone in PwMS. Methods: Sixty PwMS will be allocated to either PTE, WJ-MSCs, or a combined group, followed up for 12 months and examined using a comprehensive battery of measures. Participants in the PTE group will receive 2 sessions per week of a supervised exercise program for 6 months followed by a home exercise program for another 6 months. The WJ-MSCs group will receive 3 WJ-MSCs injections in the first 6 months then they will be encouraged to follow an active life style. The third group will receive both interventions. Discussion: This study will aid in a better understanding of the combined effect of physical therapy and mesenchymal stem cell therapy. The results from this proposed study may reduce disability, improve QOL in PwMS, and consequently, reduce the cost associated with the life-time care of these individuals worldwide.