α-Amino acid behaves differently from β- or γ-amino acids as treated by trimetaphosphate
α-Amino acid behaves differently from β- or γ-amino acids as treated by trimetaphosphate
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DOI：
10.1007/s00726-007-0599-8
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发表时间：
2008-01-01
期刊：
影响因子：
3.5
通讯作者：
Zhao, Y. F.
中科院分区：
文献类型：
--
作者：
Gao, X.;Liu, Y.;Zhao, Y. F.
用电喷雾离子阱质谱和高效液相色谱研究了三偏磷酸钠与甘氨酸、L-丙氨酸、β-丙氨酸和γ-氨基丁酸等氨基酸或氨基酸对的缩合反应。发现当混合物仅在α-氨基酸二肽存在下用三偏磷酸钠处理时形成。在不添加α-氨基酸的情况下，β-氨基酸或γ-氨基丁酸在相同条件下不能单独或与它们的混合物形成肽。从这些数据可以得出结论，磷酸盐可能选择α-氨基酸产生的肽是生命起源的重要前体。
The condensation reactions of sodium trimetaphosphate with single amino acids, namely glycine, L-alanine, beta-alanine and gamma-aminobutyric acid or pairs of these amino acids were reinvestigated by electrospray ion-trap mass spectrometry and high performance liquid chromatography. It was found when mixtures were treated by sodium trimetaphosphate only in the presence of alpha-amino acid dipeptides were formed. Without addition of alpha-amino acids, the beta-amino acid or gamma-aminobutyric acid could not form peptide either by themselves or with their mixtures under the same conditions. From the data it is concluded that phosphate might select alpha-amino acids to produce the peptides being important precursors for the origin of life.