Twenty-One Flavors of Type 1 Innate Lymphoid Cells with PD-1 (Programmed Cell Death-1 Receptor) Sprinkles
Twenty-One Flavors of Type 1 Innate Lymphoid Cells with PD-1 (Programmed Cell Death-1 Receptor) Sprinkles
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DOI：
10.1093/discim/kyad003
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发表时间：
2023-02
期刊：
影响因子：
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通讯作者：
K. Smith;G. Sciumè;Shoba Amarnath
中科院分区：
文献类型：
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作者：
K. Smith;G. Sciumè;Shoba Amarnath
摘要先天淋巴样细胞(ILCs)是近年来被发现参与启动和驱动抗肿瘤免疫反应的组织驻留免疫细胞。ILC主要分为三组，即第一类ILC(ILC1)、第二类ILC和第三类ILC。这三个组都参与了在不同癌症亚型中诱发亲肿瘤或抗肿瘤免疫反应，一致认为ILC在抗肿瘤免疫反应领域中不能被忽视。在这篇综述中，我们将具体阐述关于ILC1的知识，它们的特性，功能，以及在抗癌免疫反应中的可塑性。在此前提下，我们将讨论ILC1特性的注意事项，并扩展ILC1亚群中免疫检查点受体的表达和功能，特别是关注程序性细胞死亡-1受体在控制特定ILC1反应中的作用。我们总结说，ILC1s是启动抗肿瘤反应的重要组成部分，并且可以被检查点受体增强。
Abstract Innate lymphoid cells (ILCs) are tissue-resident immune cells that have been recently implicated in initiating and driving anti-tumor responses. ILCs are classified into three main groups, namely type 1 ILCs (ILC1), type 2 ILCs, and type 3 ILCs. All three groups have been implicated in either eliciting pro or anti-tumor immune responses in different cancer subtypes with the consensus that ILCs cannot be overlooked within the field of anti-tumor immune responses. In this review, we will specifically expand on the knowledge on ILC1, their characterization, function, and plasticity in anti-cancer immune responses. Within this premise, we will discuss caveats of ILC1 characterization, and expand on the expression and function of immune checkpoint receptors within ILC1 subsets, specifically focusing on the role of programmed cell death-1 receptor in controlling specific ILC1 responses. We summarize that ILC1s are a vital component in initiating anti-tumor responses and can be boosted by checkpoint receptors.