High-normal blood pressure is associated with poor cognitive performance
High-normal blood pressure is associated with poor cognitive performance
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DOI：
10.1161/hypertensionaha.107.105577
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发表时间：
2008-03-01
期刊：
影响因子：
8.3
通讯作者：
Ringelstein, E. Bernd
中科院分区：
文献类型：
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作者：
Knecht, Stefan;Wersching, Heike;Ringelstein, E. Bernd
收缩压（SBP）与血管事件之间的关系在高正常值范围内呈线性关系，而收缩压与认知之间的关系则不太清楚。我们在一个从中年到晚年的队列中横断面评估了收缩压和认知之间的关系。我们从总共2200名社区居民中招募了377名年龄在44至82岁之间的人（中位数：64岁，171名男性）参加SEARCH-Health研究（认知健康风险因素的系统评估和改变）。研究人员对参与者进行了全面的神经心理测试，该测试基于主成分分析，提供了认知（学习和记忆、注意力和执行功能、空间技能、工作记忆和语言技能）的5个综合分数。从综合得分的总和计算全局认知。收缩压（校正R-2 = 0.007）、教育程度（校正R-2 = 0.203）、年龄（校正R-2 = 0.102）和性别（校正R-2 = 0.011）解释了多变量分析中全球认知表现差异的三分之一（P < 0.001）。此外，收缩压（基于从< 120 mm Hg到bb0 - 170 mm Hg的10 mm Hg类别）与整体认知表现在该范围内呈线性关系，即即使在正常血压范围内也是如此（β = -0.110, P < 0.05）。亚组分析显示，收缩压与认知的关联受中年（< 60岁）个体的结果驱动（β = -0.291, P < 0.005）。因此，即使在正常血压范围内，收缩压的增加也与认知能力呈负相关。
While the relation between systolic blood pressure (SBP) and vascular events is linear down to the high-normal range, the relation between SBP and cognition is less clear. We cross-sectionally assessed the relation between SBP and cognition in a cohort extending from mid-to late-life. From a total of 2200 community-dwelling individuals we recruited 377 aged 44 to 82 years (median: 64 years, 171 male) in the SEARCH-Health study (Systematic evaluation and alteration of risk factors for cognitive health). Participants were studied with a comprehensive neuropsychological test battery that provided, based on principal component analysis, 5 composite scores for cognition (learning and memory, attention and executive function, spatial skills, working memory, and verbal skills). Global cognition was calculated from the sum of the composite scores. SBP (corrected R-2 = 0.007), education (corrected R-2 = 0.203), age (corrected R-2 = 0.102), and gender (corrected R-2 = 0.011) explained one third of variance in global cognitive performance (P < 0.001) on multivariate analyses. Moreover, the relation between SBP (based on 10 mm Hg-categories from < 120 mm Hg to > 170 mm Hg) and global cognitive performance was linear in this range of SBP-values, ie, even in the normotensive range (beta = -0.110, P < 0.05). Subgroup analysis showed that the association of SBP and cognition was driven by results in midlife (< 60 years) individuals (beta = -0.291, P < 0.005). Thus, even in the normotensive range increasing systolic blood pressure is inversely related to cognition.