Early skeletal effect of alkali therapy upon the osteomalacia of renal tubular acidosis.
Early skeletal effect of alkali therapy upon the osteomalacia of renal tubular acidosis.
复制标题
碱疗法对肾小管性酸中毒骨软化症的早期骨骼影响。
DOI：
10.1210/jcem-42-5-875
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
C. Labarrere
中科院分区：
文献类型：
--
作者：
C. Mautalen;R. Montoreano;C. Labarrere
一名患有严重肾小管性酸中毒和骨软化症的16岁女孩服用碱性药物后，尿中总羟脯氨酸排泄量几乎立即上升。可二值化部分的增量超过不可二值化部分的增量。逐渐血清磷酸盐和血清碱性磷酸酶增加，而尿钙，镁和磷酸盐清除率下降。血清甲状旁腺素始终升高。我们认为，纠正代谢性酸中毒可能会增加磷酸盐和钙跨功能性骨膜的运输，导致钙盐在未钙化基质中的快速沉积，同时增加骨胶原的周转。
The administration of alkaline agents to a 16-year-old girl with severe renal tubular acidosis and osteomalacia caused an almost immediate rise of the urinary excretion of total hydroxyproline. The increment of the dyalizable fraction predominated over the nondyalizable component. Gradually serum phosphate and serum alkaline phosphatase increased whereas urinary calcium and magnesium and phosphate clearance declined. Serum PTH remained elevated throughout. We suggest that the correction of the metabolic acidosis might increase the transport of phosphate and calcium across the functional bone membrane leading to a rapid deposition of lime salts in the uncalcified matrix with a concomitant increase in bone collagen turnover.