Neuropsychological Profile in Early-Onset Schizophrenia-Spectrum Disorders: Measured With the MATRICS Battery
Neuropsychological Profile in Early-Onset Schizophrenia-Spectrum Disorders: Measured With the MATRICS Battery
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DOI：
10.1093/schbul/sbn174
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发表时间：
2010-07-01
影响因子：
6.6
通讯作者：
Rund, Bjrn Rishovd
中科院分区：
文献类型：
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作者：
Holmen, Aina;Juuhl-Langseth, Monica;Rund, Bjrn Rishovd
目的：早发性精神分裂症（EOS）青少年存在神经认知障碍。平均概况仍然存在不一致，这可能是由于每项研究使用不同的测试。本研究的目的是检验“改善精神分裂症认知的测量和治疗研究”(MATRICS) 组合是否有助于检测患者组和健康对照之间的差异，并描述 EOS 组的神经心理学模式。方法：使用 MATRICS 电池对 31 名患有精神分裂症谱系障碍的青少年和 67 名健康对照者进行神经心理功能检查。结果：除了社会认知之外，患者和对照组在每个领域都存在显着差异。与对照组相比，患者表现出 0.8-1.8 个标准差的全身神经认知缺陷，其中言语学习、工作记忆和视觉学习是受影响最严重的领域。结论：MATRICS 电池在检测青少年人群中患者和对照之间的差异方面非常敏感。然而，我们对梅耶-萨洛维-卡鲁索情商测试在这个年龄段的使用提出质疑。结果表明，患有 EOS 的青少年存在显着的普遍缺陷。
Objective: Neurocognitive impairments have been documented in adolescents with early-onset schizophrenia (EOS). There is still inconsistency regarding an average profile, which could be due to the fact that each study uses different tests. The purpose of this study was to examine whether the "Measurement and Treatment Research to Improve Cognition in Schizophrenia" (MATRICS) battery is useful in detecting differences between the patient group and the healthy controls, and to describe the neuropsychological pattern in the EOS group. Method: Neuropsychological functioning was examined in 31 adolescents with schizophrenia spectrum disorders and 67 healthy controls, using the MATRICS battery. Results: There were significant differences between the patients and the controls on every domain except for social cognition. Patients showed a generalized neurocognitive deficit of 0.8-1.8 SDs compared with controls, with verbal learning, working memory, and visual learning being the most affected areas. Conclusions: The MATRICS battery is sensitive in detecting differences between patients and controls in the adolescent population. However, we question the use of Mayer-Salovey-Caruso Emotional Intelligence Test in this age group. Results document a significant generalized deficit in adolescents with EOS.