Development of Robust and Recoverable Ultralow-Fouling Coatings Based on Poly(carboxybetaine) Ester Analogue
Development of Robust and Recoverable Ultralow-Fouling Coatings Based on Poly(carboxybetaine) Ester Analogue
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基于聚（羧基甜菜碱）酯类似物的坚固且可恢复的超低污垢涂层的开发
DOI：
10.1021/acsami.5b05162
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发表时间：
2015-08-12
影响因子：
9.5
通讯作者：
Chen, Shengfu
中科院分区：
文献类型：
--
作者：
Wang, Guangzhi;Wang, Longgang;Chen, Shengfu
通过引入不同聚合度的端羟基PCB-ester（OH）（2）作为大分子二醇，4，4 '-二苯基甲烷二异氰酸酯（MDI）作为二异氰酸酯，1，4-丁二醇（1，4-BD）作为扩链剂，开发了基于聚羧基甜菜碱酯类似物的两性离子侧链聚氨酯（PCB-ester-PU），用于船舶涂料和生物医学应用。获得了坚固的涂层，并且在水解后对非特异性蛋白质吸附、细菌粘附和人脐静脉内皮细胞（HUVEC）附着表现出长期优异的抗性。对不同基材的附着力和膜层硬度的测试表明，该材料具有比水凝胶涂层更稳定的力学性能。此外，这种电阻不仅可以通过碱性溶液产生，而且可以通过生理缓冲液（例如磷酸盐缓冲盐水（0.15M pH 7.4 PBS））或通过高压釜中的蒸汽产生。最终，其优异的长期防污性能，通过自我再生和上级的机械性能（如硬度和弹性）的愈合能力，以及其作为极性和非极性基材上的涂料的良好可渗透性，使该材料成为海洋和医疗设备涂层的理想候选者。
Polyurethane with zwitterionic side chains (PCB-ester-PU) based on a poly(carboxybetaine) ester analogue is developed for marine coatings and biomedical applications by introducing dihydroxy-terminated PCB-ester(OH)(2) with different polymerization as the macrodiol, 4,4'-diphenylmethane diisocyanate (MDI) as the diisocyanate, and 1,4-butanediol (1,4-BD) as the chain extender. Robust coatings are obtained and exhibit long-term excellent resistance to nonspecific protein adsorption, bacterial adhesion, and human umbilical vein endothelial cell (HUVEC) attachment after hydrolysis. Tests of adhesion on different substrates and film hardness indicate that the material possesses far more stable mechanic properties than hydrogel coatings. Moreover, such a resistance can be generated not only by alkaline solution, but also by a physiological buffer (such as phosphate-buffered saline (0.15 M pH 7.4 PBS)) or by steam in an autoclave. Ultimately, its excellent long-term nonfouling property, its healing capability through self-regeneration and superior mechanic properties (such as hardness and elasticity), and its good adhesiveness as a paint on both polar and nonpolar substrates make this material an ideal candidate as a coating for marine and medical devices.