Delft University of Technology Analysis of urine, oral fluid and fingerprints by liquid extraction surface analysis coupled to high resolution MS and MS/MS-Opportunities for forensic and biomedical science
Delft University of Technology Analysis of urine, oral fluid and fingerprints by liquid extraction surface analysis coupled to high resolution MS and MS/MS-Opportunities for forensic and biomedical science
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发表时间：
2016
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通讯作者：
M. Bailey;Elizabeth C. Randall;C. Costa;T. Salter;A. Race;M. Puit;M. Koeberg;Mark Baumert;J. Bunch
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作者：
M. Bailey;Elizabeth C. Randall;C. Costa;T. Salter;A. Race;M. Puit;M. Koeberg;Mark Baumert;J. Bunch
液体萃取表面分析（LESA）是一种新型的高通量环境质谱分析工具。溶剂滴从移液器尖端沉积到表面上，并在被重新吸入之前与表面和移液器尖端保持几秒钟的接触。该技术由于其高灵敏度和低样品去除量而特别适合于表面痕量物质的分析。在这项工作中，我们评估了LESA在获取指纹、口腔液和尿液的详细化学特征方面的适用性，这些特征可能在未来用于快速医学诊断或代谢组学研究。我们进一步展示了LESA如何用于检测尿液、口腔液和指纹中的非法药物及其代谢物。这使得LESA在不断发展的指纹化学分析领域成为一个潜在的有用工具，这不仅与法医学有关，而且与医学诊断有关。最后，我们展示了如何使用LESA来检测受污染的人工手印中的爆炸性物质RDX。
Liquid Extraction Surface Analysis (LESA) is a new, high throughput tool for ambient mass spectrometry. A solvent droplet is deposited from a pipette tip onto a surface and maintains contact with both the surface and the pipette tip for a few seconds before being re-aspirated. The technique is particularly suited to the analysis of trace materials on surfaces due to its high sensitivity and low volume of sample removal. In this work, we assess the suitability of LESA for obtaining detailed chemical profiles of fingerprints, oral fluid and urine, which may be used in future for rapid medical diagnostics or metabolomics studies. We further show how LESA can be used to detect illicit drugs and their metabolites in urine, oral fluid and fingerprints. This makes LESA a potentially useful tool in the growing field of fingerprint chemical analysis, which is relevant not only to forensics but also to medical diagnostics. Finally, we show how LESA can be used to detect the explosive material RDX in contaminated artificial fingermarks.