Atherosclerosis is not a risk factor for anti-platelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery.
Atherosclerosis is not a risk factor for anti-platelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery.
复制标题
动脉粥样硬化不是体外循环手术后抗血小板因子4/肝素抗体形成的危险因素。
DOI：
10.1160/th13-12-1012
复制
发表时间：
2014
影响因子：
6.7
通讯作者：
Konkle,BarbaraA
中科院分区：
文献类型：
--
作者：
Cuker,Adam;Rauova,Lubica;Bolgiano,Douglas;MatthaiJr,WilliamH;Poncz,Mortimer;Konkle,BarbaraA
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by antibodies against complexes of platelet factor 4 (PF4) and heparin (1). HIT affects 0.5–1.4% of patients following cardiac surgery (2–4) and is associated with poor outcomes (5). Anti-PF4/heparin antibody formation is common after cardiopulmonary bypass (CPB), occurring in 22–51% at five days, 53–75% at 10 days, and 52% at six weeks (2–4, 6, 7). Although the frequency of seropositivity greatly exceeds the prevalence of clinical disease, PF4/heparin antibody formation is a prerequisite for development of HIT. An understanding of risk factors for seroconversion might allow for prospective identification of individuals at highest risk and implementation of targeted monitoring and prevention strategies.
