Patient and Parent Psychosocial Factors Associated With Health-related Quality of Life in Pediatric Inflammatory Bowel Disease
Patient and Parent Psychosocial Factors Associated With Health-related Quality of Life in Pediatric Inflammatory Bowel Disease
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DOI：
10.1097/mpg.0b013e3181f5714e
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发表时间：
2011-03-01
影响因子：
2.9
通讯作者：
Hommel, Kevin A.
中科院分区：
文献类型：
--
作者：
Herzer, Michele;Denson, Lee A.;Hommel, Kevin A.
目的：在炎症性肠病(IBD)青少年样本中，研究青少年抑郁症状在父母痛苦与青少年健康相关生活质量(HRQOL)之间的中介作用。患者和方法：62名13~17岁确诊的青少年完成了抑郁症状和HRQOL的评估。每个青少年的主要照顾者都完成了与孩子疾病相关的父母压力的测量。结果：多元回归分析表明，青少年抑郁症状完全中介了父母苦恼与HRQOL的几个维度(即总体幸福感、情绪功能、社会功能和总体HRQOL)之间的关系。此外，在统计控制了疾病严重程度、IBD诊断和显著人口学参数对HRQOL的影响后，观察了中介作用。结论：青少年抑郁症状可能是青少年IBD患者父母痛苦与较差的HRQOL联系的机制。需要密切监测父母疾病相关的痛苦和青少年抑郁症状，以及针对这些因素的临床干预，以促进患有IBD的青少年的最佳结果。
Objectives: The aim of the study was to examine the mediating role of youth depressive symptoms in the relation between parent distress and youth health-related quality of life (HRQOL) in a sample of adolescents with inflammatory bowel disease (IBD).Patients and Methods: Sixty-two adolescents, ages 13 to 17 years, with a confirmed diagnosis of IBD completed assessments of depressive symptoms and HRQOL. Each adolescent's primary caregiver completed a measure of parent stress related to his or her child's illness. Pediatric gastroenterologists provided data for disease severity assessments.Results: Multiple regression analyses revealed that adolescent depressive symptoms fully mediated the relation between parent distress and several dimensions of HRQOL (ie, general well-being, emotional functioning, social functioning, and total HRQOL). Moreover, mediation was observed after statistically controlling for the effect of disease severity, IBD diagnosis, and significant demographic parameters on HRQOL.Conclusions: Findings suggest that adolescent depressive symptoms may serve as the mechanism through which parent distress is linked to poorer HRQOL in adolescents with IBD. Close monitoring of parent illness-related distress and adolescent depressive symptoms, as well as clinical interventions targeting these factors, is needed to promote optimal outcomes in adolescents with IBD.