Rise and persistence of global M1T1 clone of Streptococcus pyogenes
Rise and persistence of global M1T1 clone of Streptococcus pyogenes
复制标题
DOI：
10.3201/eid1410.071660
复制
发表时间：
2008-10-01
影响因子：
11.8
通讯作者：
Kotb, Malak
中科院分区：
文献类型：
--
作者：
Aziz, Ramy K.;Kotb, Malak
20世纪80年代严重侵袭性A群链球菌感染的死灰复燃是传染病死灰复燃的典型例子。我们发现这种复苏是特定菌株细菌多样化的结果。在这些菌株中，有一种血清型M1T1的高毒力亚克隆，与所有其他链球菌菌株不同，它表现出不同寻常的流行病学特征和毒力。这种克隆菌株通常从非侵入性和侵入性感染病例中分离出来，最常与严重的侵入性疾病相关。由于其不寻常的流行、全球传播和毒性增加，我们研究了可能赋予其不寻常特性的独特特征。在这样做的过程中，我们发现这种克隆菌株的毒力增加可归因于其通过噬菌体动员的多样化及其感知和适应不同宿主环境的能力；因此，这个多样化的细菌群落中最适合的成员被选择生存并入侵宿主组织。
The resurgence of severe invasive group A streptococcal infections in the 1980s is a typical example of the reemergence of an infectious disease. We found that this resurgence is a consequence of the diversification of particular strains of the bacteria. Among these strains is a highly virulent subclone of serotype M1T1 that has exhibited unusual epidemiologic features and virulence, unlike all other streptococcal strains. This clonal strain, commonly isolated from both noninvasive and invasive infection cases, is most frequently associated with severe invasive diseases. Because of its unusual prevalence, global spread, and increased virulence, we investigated the unique features that likely confer its unusual properties. In doing so, we found that the increased virulence of this clonal strain can be attributed to its diversification through phage mobilization and its ability to sense and adapt to different host environments; accordingly, the fittest members of this diverse bacteria[ community are selected to survive and invade host tissue.