Insulin-like growth factors (IGF I and IGF II) mimic the effect of insulin on plasma protein synthesis and glycogen deposition in cultured hepatocytes.
Insulin-like growth factors (IGF I and IGF II) mimic the effect of insulin on plasma protein synthesis and glycogen deposition in cultured hepatocytes.
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胰岛素样生长因子（IGF I 和 IGF II）模拟胰岛素对培养肝细胞中血浆蛋白合成和糖原沉积的影响。
DOI：
10.1016/0006-291x(86)90581-4
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发表时间：
1986
影响因子：
3.1
通讯作者：
Grieninger,G
中科院分区：
文献类型：
--
作者：
Parkes,JL;Cardell,RR;Grieninger,G
采用鸡胚肝细胞单层培养，比较胰岛素样生长因子IGF I和IGF II与胰岛素对两种肝功能：血浆蛋白产生和糖原沉积的影响。正如与暴露的细胞胰岛素，无论是IGF I或IGF II，否则无糖培养基引起了显着的变化，分泌蛋白质的生产，以及相当于在体内（喂养）水平的糖原沉积的发展。胰岛素、IGF I或IGF II之间在激素的刺激程度或效力方面没有观察到重大差异。
Monolayer cultures of chick embryo hepatocytes were used to compare the effects of insulin-like growth factors, IGF I and IGF II, with insulin on two hepatic functions: plasma protein production and glycogen deposition. Just as with exposure of the cells to insulin, addition of either IGF I or IGF II to the otherwise hormone-free medium elicited a dramatic change in the production of secretory proteins as well as the development of glycogen deposits equivalent to in vivo (fed) levels. No major differences between insulin, IGF I or IGF II were observed in terms of the degree of stimulation or potency of the hormones.