13CO2 washout dynamics during intermittent exercise in children and adults.
13CO2 washout dynamics during intermittent exercise in children and adults.
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儿童和成人间歇运动期间的 13CO2 冲刷动态。
DOI：
10.1152/jappl.1992.73.6.2476
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Landaw,E
中科院分区：
文献类型：
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作者：
Zanconato,S;Cooper,DM;Barstow,TJ;Landaw,E
为了验证儿童在运动中储存的二氧化碳比成年人少的假设，我们测量了9名儿童[8+/-1(SD)岁，4名男孩]和9名(28+/-6岁，5名男性)成人口服[13C]碳酸氢盐后的呼吸13CO2排出动力学。气体交换[O2摄取和二氧化碳产生(VCO2)]是在休息时和间歇运动时的呼吸中测量的。采集呼气样品，进行13CO2的同位素比值质谱分析。VCO_2示踪剂估计值与气体交换测定的VCO_2值高度相关(r=0.97P<；0.0001)。安静和运动时，儿童的平均停留时间(50±5分钟)明显短于成人(69±7分钟，P<；0.0001)(儿童为35±7分钟；成人为50±11分钟，P<；0.001)。在儿童(254+/-36毫升/公斤)和成人(232+/-37毫升/公斤)之间，估计储存的二氧化碳(使用气体交换测量的平均VCO2和由示踪剂清洗得出的平均停留时间)在统计学上没有差异。在运动过程中，成年人的二氧化碳储存量(340+/-46ml/kg)比安静时显著增加(P<；0.001)，但儿童的二氧化碳储存量没有增加(平均运动值为254ml/kg)。这些数据支持了这样一种假设，即在生长期内，运动对二氧化碳分布的响应会发生变化。
To test the hypothesis that children store less CO2 than adults during exercise, we measured breath 13CO2 washout dynamics after oral bolus of [13C]bicarbonate in nine children [8 +/- 1 (SD) yr, 4 boys] and nine (28 +/- 6 yr, 5 males) adults. Gas exchange [O2 uptake and CO2 production (Vco2)] was measured breath by breath during rest and during light (80% of the anaerobic threshold) intermittent exercise. Breath samples were obtained for subsequent analysis of 13CO2 by isotope ratio mass spectrometry. The tracer estimate of Vco2 was highly correlated to Vco2 measured by gas exchange (r = 0.97, P < 0.0001). The mean residence time was shorter in children (50 +/- 5 min) compared with adults (69 +/- 7 min, P < 0.0001) at rest and during exercise (children, 35 +/- 7 min; adults, 50 +/- 11 min, P < 0.001). The estimate of stored CO2 (using mean Vco2 measured by gas exchange and mean residence time derived from tracer washout) was not statistically different at rest between children (254 +/- 36 ml/kg) and adults (232 +/- 37 ml/kg). During exercise, CO2 stores in the adults (304 +/- 46 ml/kg) were significantly increased over rest (P < 0.001), but there was no increase in children (mean exercise value, 254 +/- 38 ml/kg). These data support the hypothesis that CO2 distribution in response to exercise changes during the growth period.