Dorsal cortical regions subserving visually guided saccades in humans: An fMRI study
Dorsal cortical regions subserving visually guided saccades in humans: An fMRI study
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DOI：
10.1093/cercor/8.1.40
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发表时间：
1998-01-01
期刊：
影响因子：
3.7
通讯作者：
Sweeney, JA
中科院分区：
文献类型：
--
作者：
Luna, B;Thulborn, KR;Sweeney, JA
对非人类灵长类动物的神经生理学研究已经确定了皮质区域中与扫视相关的神经元活动，包括额叶 (FEF)、辅助 (SEF) 和顶叶眼区。病变和神经影像学研究表明，人类动眼系统的映射通常是同源的；然而，这些功能区域的精确解剖位置的详细绘图尚未实现。我们使用功能磁共振成像 (fMRI) 对 10 名成年受试者进行眼跳任务和中央注视期间的背额叶和顶叶皮层进行了研究。 FEF 仅限于中央前沟，并且没有向前延伸到 Brodmann 8 区，传统上该区域被视为人类的位置。 SEF 位于大脑半球间裂的皮质中，并最小程度地延伸到背侧皮质表面。在楔前叶和沿顶内沟可见顶叶激活，延伸至顶上小叶和顶下小叶。这些发现定位了人类额叶和顶叶皮层中参与眼跳生成的区域，并表明额叶和顶叶皮层与猕猴的显着差异。这些差异可能对这些区域在视觉运动过程中发挥的作用产生功能影响。
Neurophysiological studies in non-human primates have identified saccade related neuronal activity in cortical regions including frontal (FEF), supplementary (SEF) and parietal eye fields. Lesion and neuroimaging studies suggest a generally homologous mapping of the oculomotor system in humans; however, a detailed mapping of the precise anatomical location of these functional regions has not yet been achieved. We investigated dorsal frontal and parietal cortex during a saccade task vs. central fixation in 10 adult subjects using functional magnetic resonance imaging (fMRI). The FEF were restricted to the precentral sulcus, and did not extend anteriorly into Brodmann area 8, which has traditionally been viewed as their location in humans. The SEF were located in cortex along the interhemispheric fissure and extended minimally onto the dorsal cortical surface. Parietal activation was seen in precuneus and along the intraparietal sulcus, extending into both superior and inferior parietal lobules. These findings localize areas in frontal and parietal cortex involved in saccade generation in humans, and indicate significant differences from the macaque monkey in both frontal and parietal cortex. These differences may have functional implications for the roles these areas play in visuomotor processes.