Drug release behaviour and mechanism from unmodified and in situ modified bacterial cellulose
Drug release behaviour and mechanism from unmodified and in situ modified bacterial cellulose
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DOI：
10.1007/s43538-021-00012-x
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发表时间：
2021-03-01
影响因子：
0.9
通讯作者：
Khandelwal, Mudrika
中科院分区：
文献类型：
--
作者：
Adepu, Shivakalyani;Khandelwal, Mudrika
细菌纤维素（BC）具有纳米纤维状的微孔和介孔结构，是一种理想的药物载体。其中一个独特的方面是在细菌合成纤维素的过程中，通过在生长培养基中添加某些添加剂来调节BC微观结构。在本工作中，BC原位改性，通过添加聚乙二醇2000（PEG 2000）。采用XRD、FTIR、SEM和BET等手段研究了原位改性对纳米复合材料的结晶度、化学组成、微观结构和形貌以及孔隙率的影响，以及对药物（双氯芬酸钠）的载药量和释药动力学的影响。PEG 2000作为非原位改性剂，提高了聚合物的总孔隙率、孔容，降低了比表面积，但对结晶度无明显影响。在体外，药物释放研究显示，与原始BC相比，PEG修饰的BC具有巨大的爆发释放。通过数学建模进一步研究了释放机制。这项工作开辟了探索调整细菌纤维素的立即和持续药物释放的各种释放应用的广泛可能性的途径。
Bacterial cellulose (BC) is a suitable drug delivery carrier owing to the nanofibrous micro and mesoporous structure. One of the unique aspects is the tunability of BC microstructure by the addition of certain additives in the growth medium during the synthesis of cellulose by bacteria. In the present work, BC was in situ modified by adding Polyethylene glycol 2000 (PEG 2000). Effect of in situ modification on crystallinity, chemical composition, microstructure and morphology and, porosity was studied by XRD, FTIR, SEM and BET, followed by the effect on drug (Diclofenac sodium) loading and release kinetics. As a non-incorporating in situ modifier, PEG2000 increased the overall porosity, pore volume and decreased the specific surface area with no significant effect on crystallinity. In vitro, drug release studies revealed that a huge burst release for PEG modified BC as compared to pristine BC. The mechanism of release is further investigated by mathematical modelling. This work opens up avenues of exploring the wide possibility of tuning immediate and sustained drug release from bacterial cellulose for various release applications.