Cellular evidence for efference copy in Drosophila visuomotor processing
Cellular evidence for efference copy in Drosophila visuomotor processing
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DOI：
10.1038/nn.4083
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发表时间：
2015-09-01
影响因子：
25
通讯作者：
Maimon, Gaby
中科院分区：
文献类型：
--
作者：
Kim, Anmo J.;Fitzgerald, Jamie K.;Maimon, Gaby
每次移动的苍蝇转身时，视觉图像都会扫过视网膜并产生运动刺激。经典的行为学实验表明，苍蝇在预定的转弯中使用活跃的神经回路机制来抑制对自我产生的视觉运动的感知。然而，一直缺乏直接的电生理证据。我们发现果蝇的视觉神经元在快速飞行转弯时接受与运动相关的输入。这些输入带有适当的标志和潜伏期，以抑制每个目标细胞对该转折的视觉反应。对行为和神经元反应潜伏期的精确测量支持了这样的观点，即运动相关的输入到视流处理细胞代表了对自愿转弯诱导的预期视觉驱动的内部预测。对小的物体选择性视神经元的运动相关输入既可以反映转向的本体感觉反馈，也可以反映内部产生的信号。我们在果蝇身上的结果呼应了灵长类动物快速眼球运动时视觉感知的抑制，展示了跨门感觉运动处理的共同功能原理。
Each time a locomoting fly turns, the visual image sweeps over the retina and generates a motion stimulus. Classic behavioral experiments suggested that flies use active neural-circuit mechanisms to suppress the perception of self-generated visual motion during intended turns. Direct electrophysiological evidence, however, has been lacking. We found that visual neurons in Drosophila receive motor-related inputs during rapid flight turns. These inputs arrived with a sign and latency appropriate for suppressing each targeted cell's visual response to the turn. Precise measurements of behavioral and neuronal response latencies supported the idea that motor-related inputs to optic flow-processing cells represent internal predictions of the expected visual drive induced by voluntary turns. Motor-related inputs to small object-selective visual neurons could reflect either proprioceptive feedback from the turn or internally generated signals. Our results in Drosophila echo the suppression of visual perception during rapid eye movements in primates, demonstrating common functional principles of sensorimotor processing across phyla.