Dynamic change and impact of myeloid-derived suppressor cells in allogeneic bone marrow transplantation in mice.
Dynamic change and impact of myeloid-derived suppressor cells in allogeneic bone marrow transplantation in mice.
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髓样衍生的抑制细胞在小鼠同种异体骨髓移植中的动态变化和影响。
DOI：
10.1016/j.bbmt.2013.01.008
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发表时间：
2013-05
影响因子：
4.3
通讯作者：
Yu, Xue-Zhong
中科院分区：
文献类型：
--
作者：
Wang, Dapeng;Yu, Yu;Haarberg, Kelley;Fu, Jianing;Kaosaard, Kane;Nagaraj, Srinivas;Anasetti, Claudio;Gabrilovich, Dmitry;Yu, Xue-Zhong
髓源性抑制细胞(MDSCs)是由造血祖细胞、未成熟巨噬细胞、树突状细胞和粒细胞组成的一组髓系细胞，聚集在炎症性疾病和各种癌症中。在这里，我们研究了MDSCs在移植物抗宿主病(GVHD)发展和/或异基因骨髓移植(BMT)后肿瘤复发中的动态变化和作用。我们发现，在供者移植物中添加功能性MDSCs可以缓解GVHD，而体内移除MDSCs会加剧GVHD。在T细胞耗尽的骨髓移植后，MDSCs在非GVHD受者的血液和脾中短暂积聚；相反，在T细胞完全充盈的BMT后，GVHD受者的血液MDSCs水平持续升高。MDSC积聚与GVHD严重程度呈正相关。此外，肿瘤复发后，MDSC积聚进一步增加。虽然从同基因和异基因骨髓移植受者分离的MDSCs在体外对同种异体抗原刺激的T细胞增殖有抑制作用，但GVHD受者的MDSCs比非GVHD受者的MDSCs显示出更高的抑制能力。这些结果表明，MDSCs可以调节异基因骨髓移植后急性移植物抗宿主病(GVHD)和肿瘤复发的免疫反应。
Myeloid-derived suppressor cells (MDSCs) are a group of myeloid cells comprised of hematopoietic progenitor cells, immature macrophages, dendritic cells and granulocytes, which accumulate in inflammatory diseases and various cancers. Here, we investigated the dynamic changes and effects of MDSCs in graft-versus-host disease (GVHD) development and/or tumor relapse after syngeneic and allogeneic bone marrow transplantation (BMT). We found that adding functional MDSCs in donor graft alleviated GVHD, whereas removal of MDSCs in vivo exacerbated GVHD. Following T cell-deplete BMT, MDSCs transiently accumulated in the blood and spleen of recipients without GVHD; In contrast, after T cell-replete BMT, the levels of blood MDSCs were constantly elevated in recipients with GVHD. MDSC accumulation positively correlated with the severity of GVHD. Additionally, MDSC accumulation was further increased upon tumor relapse. Although MDSCs isolated from both syngeneic and allogeneic BMT recipients inhibited T-cell proliferation in response to alloantigen stimulation ex vivo, MDSCs from the recipients with GVHD showed much higher suppressive potency compared to those from recipients without GVHD. These results indicate that MDSCs can regulate the immune response in acute GVHD, and possibly tumor relapse, subsequent to allogeneic BMT.
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影响因子：
82.9
作者：
Nagaraj, Srinivas;Gupta, Kapil;Gabrilovich, Dmitry I.
通讯作者：
Gabrilovich, Dmitry I.
影响因子：
20.3
作者：
Movahedi, Kiavash;Guilliams, Martin;Van Ginderachter, Jo A.
通讯作者：
Van Ginderachter, Jo A.
影响因子：
20.3
作者：
Highfill, Steven L.;Rodriguez, Paulo C.;Blazar, Bruce R.
通讯作者：
Blazar, Bruce R.
DOI：
10.1053/bbmt.1999.v5.pm10392958
发表时间：
1999-01-01
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Johnson, B D;Becker, E E;Truitt, R L
通讯作者：
Truitt, R L
影响因子：
11.2
作者：
Mirza, Noweeda;Fishman, Mayer;Gabrilovich, Dmitry I.
通讯作者：
Gabrilovich, Dmitry I.