Using a Targeted Proteomics Chip to Explore Pathophysiological Pathways for Incident Diabetes-The Malmo Preventive Project
Using a Targeted Proteomics Chip to Explore Pathophysiological Pathways for Incident Diabetes-The Malmo Preventive Project
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DOI：
10.1038/s41598-018-36512-y
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发表时间：
2019-01-22
影响因子：
4.6
通讯作者：
Magnusson, Martin
中科院分区：
文献类型：
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作者：
Molvin, John;Pareek, Manan;Magnusson, Martin
多重蛋白质组学平台为研究多种蛋白质与疾病之间的关联提供了极好的工具（例如，糖尿病），可能具有预后、诊断和治疗意义。在这项研究中，我们的目的是通过检查92种蛋白质及其与基于人群的队列（146例糖尿病患者与880例对照）中糖尿病事件的相关性，探索新的病理生理学途径，随访8年以上。在调整传统风险因素后，我们确定了七种与糖尿病相关的蛋白质。4种蛋白质（富含清道夫受体半胱氨酸的1型蛋白质M130、脂肪酸结合蛋白4、纤溶酶原激活物抑制剂1和胰岛素样生长因子结合蛋白2）与先前确定的糖尿病发病相关，3种蛋白质（组织蛋白酶D、半乳糖凝集素-4、对氧磷酶3型）与糖尿病发病新相关。半乳糖凝集素-4与糖尿病风险增加，对氧磷酶3型与糖尿病风险降低，在调整血糖后仍与糖尿病事件显著相关，这意味着与糖尿病的葡萄糖非依赖性相关。
Multiplex proteomic platforms provide excellent tools for investigating associations between multiple proteins and disease (e.g., diabetes) with possible prognostic, diagnostic, and therapeutic implications. In this study our aim was to explore novel pathophysiological pathways by examining 92 proteins and their association with incident diabetes in a population-based cohort (146 cases of diabetes versus 880 controls) followed over 8 years. After adjusting for traditional risk factors, we identified seven proteins associated with incident diabetes. Four proteins (Scavenger receptor cysteine rich type 1 protein M130, Fatty acid binding protein 4, Plasminogen activator inhibitor 1 and Insulin-like growth factor-binding protein 2) with a previously established association with incident diabetes and 3 proteins (Cathepsin D, Galectin-4, Paraoxonase type 3) with a novel association with incident diabetes. Galectin-4, with an increased risk of diabetes, and Paraoxonase type 3, with a decreased risk of diabetes, remained significantly associated with incident diabetes after adjusting for plasma glucose, implying a glucose independent association with diabetes.