Plasma concentrations of carotenoids, retinol, and tocopherols in preeclamptic and normotensive pregnant women.
Plasma concentrations of carotenoids, retinol, and tocopherols in preeclamptic and normotensive pregnant women.
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先兆子痫和血压正常孕妇的类胡萝卜素、视黄醇和生育酚的血浆浓度。
DOI：
10.1093/aje/153.6.572
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发表时间：
2001
影响因子：
5
通讯作者：
Leisenring,WM
中科院分区：
文献类型：
--
作者：
Zhang,C;Williams,MA;Sanchez,SE;King,IB;Ware-Jauregui,S;Larrabure,G;Bazul,V;Leisenring,WM
这项病例对照研究于1997年6月至1998年1月在秘鲁利马进行，旨在评估子痫前期妇女血浆类胡萝卜素(α-胡萝卜素、β-胡萝卜素、番茄红素、叶黄素、玉米黄质、β-隐黄质)、视黄醇和生育酚(α-生育酚和γ-生育酚)浓度是否降低。共有125名患有先兆子痫的孕妇和179名血压正常的孕妇纳入研究。用高效液相色谱法测定抗氧化剂的血浆浓度。在调整了母亲的人口学、行为、生殖特征和总血脂浓度后，作者发现，随着α-生育酚浓度的增加，先兆子痫的风险呈线性增加(最高四分位数的优势比=3.13；95%可信区间：1.0 6，9.23，以最低四分位数为参考组；线性趋势检验的p值=0.040)。子痫前期的风险随着视黄醇浓度的增加而降低(最高的四分位数的优势比=0.32；95%可信区间：0.15，0.69，以最低的四分位数为参考组；线性趋势检验的p值=0.001)。其中一些结果与普遍的假设不一致，即先兆子痫是一种抗氧化不足的状态。初步研究结果证实，与正常血压的孕妇相比，先兆子痫妇女的血浆α-生育酚浓度较早有升高的观察。
This case-control study was conducted in Lima, Peru, from June 1997 through January 1998 to assess whether plasma concentrations of carotenoids (α-carotene, β-carotene, lycopene, lutein, zeaxanthin, β-cryptoxanthin), retinol, and tocopherols (α-tocopherol and γ-tocopherol) are decreased in women with preeclampsia. A total of 125 pregnant women with preeclampsia and 179 normotensive pregnant women were included. Plasma concentrations of antioxidants were determined using high performance liquid chromatography. After adjusting for maternal demographic, behavioral, and reproductive characteristics and total plasma lipid concentrations, the authors found a linear increase in risk of preeclampsia with increasing concentrations of α-tocopherol (odds ratio of the highest quartile = 3.13; 95% confidence interval: 1.06, 9.23, with the lowest quartile as the reference group;pvalue of the test of linear trend = 0.040). The risk of preeclampsia decreased across increasing quartiles of concentrations for retinol (odds ratio of the highest quartile = 0.32; 95% confidence interval: 0.15, 0.69, with the lowest quartile as the reference group;pvalue of the test of linear trend = 0.001). Some of these results are inconsistent with the prevailing hypothesis that preeclampsia is an antioxidant-deficient state. Preliminary findings confirm an earlier observation of increased plasma concentrations of α-tocopherol among women with preeclampsia as compared with normotensive pregnant women.