Strontium borate glass: potential biomaterial for bone regeneration
Strontium borate glass: potential biomaterial for bone regeneration
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DOI：
10.1098/rsif.2009.0504
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发表时间：
2010-07-06
影响因子：
3.9
通讯作者：
Chang, J.
中科院分区：
文献类型：
--
作者：
Pan, H. B.;Zhao, X. L.;Chang, J.
硼在胚胎发生、骨骼生长和维持、免疫功能和精神运动技能等许多生命过程中起着重要作用。因此，通过硼酸盐玻璃的降解来输送硼在生物医学应用中具有特殊的意义。然而，由于硼的快速释放而产生的硼酸盐玻璃的细胞毒性必须仔细考虑。本研究发现，将锶掺入硼酸玻璃中，不仅可以减缓硼的快速释放，还可以诱导成骨样细胞SaOS-2的粘附，从而显著提高硼酸玻璃的细胞相容性。多层多孔结构磷灰石的形成表明完全降解是乐观的，磷灰石覆盖的SaOS-2扩散形成三明治结构可能在早期诱导骨样组织的形成。因此，这种新型的含锶硼硅酸盐可能作为新一代的骨再生生物材料，它不仅使硼成为骨骼健康的营养元素，而且还能传递锶来刺激新骨骼的形成。
Boron plays important roles in many life processes including embryogenesis, bone growth and maintenance, immune function and psychomotor skills. Thus, the delivery of boron by the degradation of borate glass is of special interest in biomedical applications. However, the cytotoxicity of borate glass which arises with the rapid release of boron has to be carefully considered. In this study, it was found that the incorporation of strontium into borate glass can not only moderate the rapid release of boron, but also induce the adhesion of osteoblast-like cells, SaOS-2, thus significantly increasing the cyto-compatibility of borate glass. The formation of multilayers of apatite with porous structure indicates that complete degradation is optimistic, and the spread of SaOS-2 covered by apatite to form a sandwich structure may induce bone-like tissue formation at earlier stages. Therefore, such novel strontium-incorporated borosilicate may act as a new generation of biomaterial for bone regeneration, which not only renders boron as a nutritious element for bone health, but also delivers strontium to stimulate formation of new bones.