Nutrition and immunity: An overview
Nutrition and immunity: An overview
复制标题
DOI：
10.1093/jn/124.suppl_8.1433s
复制
发表时间：
1994-01-01
影响因子：
4.2
通讯作者：
Kumari, Sobha
中科院分区：
文献类型：
--
作者：
Chandra, Ranjit Kumar;Kumari, Sobha
历史记录和最近的流行病学研究表明，营养不良和感染之间存在着相互加剧的关系。在蛋白质-能量营养不良中，免疫的几个方面都有明显的损害，包括细胞介导的免疫反应、分泌性免疫球蛋白a抗体的产生、吞噬细胞功能、补体系统、抗体亲和力和细胞因子的产生。几种微量营养素在维持最佳免疫反应中起着至关重要的作用。另一方面，过量摄入营养物质也会损害免疫力。喂食缺乏核苷酸的饲料的动物的免疫反应比对照组低，但当饮食中含有大量核苷酸时，免疫反应并没有增强。这些观察结果在设计饲粮配方方面具有相当大的实际意义。
Historical accounts and recent epidemiologic studies have suggested a mutually aggravating relationship between malnutrition and infection. In protein-energy malnutrition, there is a significant impairment of several aspects of immunity, including cell-mediated immune responses, secretory immunoglobulin A antibody production, phagocyte function, complement system, antibody affinity and cytokine production. Several micronutrients play a crucial role in maintenance of optimum immune responses. On the other hand, excessive intake of nutrients also impairs immunity. Animals fed diets lacking in nucleotides have lower immune responses than controls but there is no enhancement of immunity when the diet contains large amounts of nucleotides. These observations have considerable practical importance in terms of designing feeding formulas.