Effects of neoglycoproteins on penetration of Plasmodium falciparum merozoites into erythrocytes in vitro.
Effects of neoglycoproteins on penetration of Plasmodium falciparum merozoites into erythrocytes in vitro.
复制标题
新糖蛋白对体外恶性疟原虫裂殖子渗透红细胞的影响。
DOI：
--
复制
发表时间：
1984
影响因子：
1.3
通讯作者：
J. Vanderberg
中科院分区：
文献类型：
--
作者：
S. Schulman;Y. C. Lee;J. Vanderberg
在体外抑制试验中，测试了与牛血清白蛋白缀合的糖（新糖蛋白）抑制恶性疟原虫裂殖子侵入红细胞的能力。通过评估3H-次黄嘌呤掺入培养物中来确定新糖蛋白对红细胞裂殖子侵袭的抑制作用。唯一对 N-乙酰氨基葡萄糖-牛血清白蛋白产生显着抑制作用的新糖蛋白。 N-乙酰基-葡糖胺和N-乙酰基-葡糖胺-牛血清白蛋白的抑制效果的比较表明，N-乙酰基-葡糖胺-牛血清白蛋白对3H-次黄嘌呤掺入的50％抑制效果是游离糖的84倍。
Sugars conjugated to bovine serum albumin (neoglycoproteins) were tested for their ability to inhibit Plasmodium falciparum merozoite invasion of red blood cells in an in vitro inhibition assay. The inhibitory effects of the neoglycoproteins on merozoite invasion of erythrocytes were determined by assessing 3H-hypoxanthine incorporation into the cultures. The only neoglycoprotein that caused significant inhibition N-acetyl-glucosamine-bovine serum albumin. A comparison of the inhibitory effects of N-acetyl-glucosamine and N-acetyl-glucosamine-bovine serum albumin showed that N-acetyl-glucosamine-bovine serum albumin was 84 fold more effective than the free sugar in causing 50% inhibition of 3H-hypoxanthine incorporation.
使用 2-亚氨基-2-甲氧基乙基 1-硫代糖苷通过牛血清白蛋白脒化制备一些新的新糖蛋白。
影响因子：
2.9
作者：
Stowell,CP;Lee,YC
通讯作者：
Lee,YC