A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents
A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents
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DOI：
10.1016/j.bmcl.2005.08.053
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发表时间：
2005-12-01
影响因子：
2.7
通讯作者：
Chauhan, PMS
中科院分区：
文献类型：
--
作者：
Agarwal, A;Srivastava, K;Chauhan, PMS
合成了一个20个三取代嘧啶类化合物的小型库，并对其体外抗疟和抗结核活性进行了评价。在全部筛选的化合物中，16种化合物在0.25-2 μ g/mL范围内显示出抗恶性疟原虫的体外抗疟活性，8种化合物在12.5 μ g/mL浓度下显示出抗结核分枝杆菌H37 Ra的抗结核活性。(c)2005爱思唯尔有限公司保留所有权利。
A small library of 20 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activity. Out of the total screened compounds, 16 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25-2 mu g/mL and 8 compounds have shown antitubercular activity against Mycobacterium tuberculosis H37Ra, at a concentration of 12.5 mu g/mL. (c) 2005 Elsevier Ltd. All rights reserved.