Maintaining monodispersity in a microbubble population formed by flow-focusing
Maintaining monodispersity in a microbubble population formed by flow-focusing
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DOI：
10.1021/la703065v
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发表时间：
2008-03-04
期刊：
影响因子：
3.9
通讯作者：
Longo, Marjorie L.
中科院分区：
文献类型：
--
作者：
Talu, Esra;Hettiarachchi, Kanaka;Longo, Marjorie L.
利用视频光学显微镜观察了影响流动聚焦形成脂质微泡粒径分布的动力学过程。研究的参数包括填充气体，气体饱和周围的溶液，和微泡尺寸（初始尺寸2-12 μ m），以模拟典型的实验室条件。通常，观察并定量溶解或生长，然后在收集盖玻片处进行奥斯特瓦尔德熟化。然而，在被空气饱和溶液包围的小的充氮微泡的情况下，至少9 h内避免了奥斯特瓦尔德熟化。这些气泡具有1.5 +/-0.1 μ m的最终尺寸分布。这项工作表明，通过流动聚焦形成的脂质封装的微泡应给予足够的时间以在彼此接触之前达到终端尺寸。这些长寿命的单分散微泡应该在超声造影剂，微细加工，食品和研究应用的兴趣。
The dynamic processes impacting the size distributions of lipid-encapsulated microbubbles formed by flow-focusing were observed by video optical microscopy. Parameters studied included the filling gas, gas saturating the surrounding solution, and microbubble size (initial size 2-12 mu m) to simulate typical laboratory conditions. Typically, dissolution or growth, followed by Ostwald ripening at a collection cover glass, were observed and quantified. However, in the case of small nitrogen-filled microbubbles surrounded by an air-saturated solution, Ostwald ripening was avoided for at least 9 h. These bubbles had a final size distribution of 1.5 +/- 0.1 mu m. This work suggests that lipid-encapsulated microbubbles formed by flow-focusing should be given sufficient time to reach a terminal size before coming into contact with each other. These long-lived mondisperse microbubbles should be of interest in ultrasound contrast agents, microfabrication, food, and research applications.