Cell-Type-Specific Outcome Representation in the Primary Motor Cortex
Cell-Type-Specific Outcome Representation in the Primary Motor Cortex
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DOI：
10.1016/j.neuron.2020.06.006
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发表时间：
2020-09-09
期刊：
影响因子：
16.2
通讯作者：
Schiller, Jackie
中科院分区：
文献类型：
--
作者：
Levy, Shahar;Lavzin, Maria;Schiller, Jackie
适应性运动对于动物的生存至关重要。为了指导未来的行动，大脑会监控各种结果，包括运动和食欲目标的实现。这些结果信号的性质及其在指导熟练运动的运动皮层 (M1) 中的神经元和网络实现在很大程度上是未知的。通过灵巧任务、钙成像、光遗传学扰动和行为操作，我们研究了小鼠前肢 M1 的结果信号。我们发现了两个 2-3 层神经元群体，称为成功相关神经元和失败相关神经元，它们通过训练而发展，并报告试验的最终结果。在这些神经元中，在成功或失败的试验后记录了长时间的反应，与奖励和运动学无关。此外，第 5 层锥体束神经元的初始状态包含先前试验结果的记忆痕迹。学习新的任务要求需要试验间皮质活动。这些 M1 层特定的表现结果信号可能支持技能行为的强化运动学习。
Adaptive movements are critical for animal survival. To guide future actions, the brain monitors various outcomes, including achievement of movement and appetitive goals. The nature of these outcome signals and their neuronal and network realization in the motor cortex (M1), which directs skilled movements, is largely unknown. Using a dexterity task, calciumimaging, optogenetic perturbations, and behavioral manipulations, we studied outcome signals in the murine forelimb M1. We found two populations of layer 2-3 neurons, termed success- and failure-related neurons, that develop with training, and report end results of trials. In these neurons, prolonged responses were recorded after success or failure trials independent of reward and kinematics. In addition, the initial state of layer 5 pyramidal tract neurons contained a memory trace of the previous trial's outcome. Intertrial cortical activity was needed to learn new task requirements. These M1 layer-specific performance outcome signals may support reinforcement motor learning of skilled behavior.