Beam path toxicities to non-target structures during intensity-modulated radiation therapy for head and neck cancer
Beam path toxicities to non-target structures during intensity-modulated radiation therapy for head and neck cancer
复制标题
DOI：
10.1016/j.ijrobp.2008.01.012
复制
发表时间：
2008-11-01
影响因子：
7
通讯作者：
Garden, Adam S.
中科院分区：
文献类型：
--
作者：
Rosenthal, David I.;Chambers, Mark S.;Garden, Adam S.
背景：在头颈癌（HNC）的三维适形放射治疗（3D-CRT）中，调强放射治疗（IMRT）光束穿过未照射的非靶正常结构。本研究估计了IMRT期间对非靶结构的剂量和毒性。材料与方法：回顾性分析口咽癌IMRT和3D-CRT病例。使用剂量-体积直方图（DVH）评估辐射剂量对唇部、耳蜗、脑干、枕部头皮和下颌骨的影响。比较3D-CRT、单独IMRT或IMRT联合顺铂的毒性率。描述性统计和探索性递归划分分析用于估计与观察到的毒性相关的剂量“断点”。结果：共对160例患者进行毒性评估，60例进行详细的DVH评估，15例进行3D-CRT方案比较。IMRT与3D-CRT比较，差异有统计学意义(p
Background: Intensity-modulated radiation therapy (IMRT) beams traverse nontarget normal structures not irradiated during three-dimensional conformal RT (3D-CRT) for head and neck cancer (HNC). This study estimates the doses and toxicities to nontarget structures during IMRT.Materials and Methods: Oropharyngeal cancer IMRT and 3D-CRT cases were reviewed. Dose-volume histograms (DVH) were used to evaluate radiation dose to the lip, cochlea, brainstem, occipital scalp, and segments of the mandible. Toxicity rates were compared for 3D-CRT, IMRT alone, or IMRT with concurrent cisplatin. Descriptive statistics and exploratory recursive partitioning analysis were used to estimate dose "breakpoints" associated with observed toxicities.Results: A total of 160 patients were evaluated for toxicity, 60 had detailed DVH evaluation and 15 had 3D-CRT plan comparison. Comparing IMRT with 3D-CRT, there was significant (p