Spontaneous assembly of chemically encoded two-dimensional coacervate droplet arrays by acoustic wave patterning.
Spontaneous assembly of chemically encoded two-dimensional coacervate droplet arrays by acoustic wave patterning.
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DOI：
10.1038/ncomms13068
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发表时间：
2016-10-06
影响因子：
16.6
通讯作者：
Mann, Stephen
中科院分区：
文献类型：
--
作者：
Tian, Liangfei;Martin, Nicolas;Bassindale, Philip G.;Patil, Avinash J.;Li, Mei;Barnes, Adrian;Drinkwater, Bruce W.;Mann, Stephen
通过声波驻波压力场和原位复杂凝聚的结合，在水介质中实现了化学编码、分子拥挤、富含水的微滴自发组装成周期性无缺陷的二维阵列。声学介导的初级液滴聚结产生每个节点单个液滴的微阵列，表现出可变的表面附着特性，自发地吸收染料、酶和颗粒，并在暴露于反应物扩散梯度时显示空间和时间依赖的荧光输出。此外，通过抑制聚结来制备具有动态行为和物质交换的凝聚型液滴阵列，以产生声捕获的液滴簇晶格，这些晶格在形状和空间构型上显示快速和可逆的变化，直接响应声频和场的调制。我们的研究结果为设计和构建具有可控空间组织、可编程信号通路和高阶集体行为的“水中水”微液滴阵列提供了一条新途径。分离的液滴可以作为微反应器，但在溶液中进行功能操作和观察液滴之间的化学交换具有挑战性。在这里，Tian等人使用声阱将水基微滴组装成周期性阵列，从溶液介质中自发分离。
The spontaneous assembly of chemically encoded, molecularly crowded, water-rich micro-droplets into periodic defect-free two-dimensional arrays is achieved in aqueous media by a combination of an acoustic standing wave pressure field and in situ complex coacervation. Acoustically mediated coalescence of primary droplets generates single-droplet per node micro-arrays that exhibit variable surface-attachment properties, spontaneously uptake dyes, enzymes and particles, and display spatial and time-dependent fluorescence outputs when exposed to a reactant diffusion gradient. In addition, coacervate droplet arrays exhibiting dynamical behaviour and exchange of matter are prepared by inhibiting coalescence to produce acoustically trapped lattices of droplet clusters that display fast and reversible changes in shape and spatial configuration in direct response to modulations in the acoustic frequencies and fields. Our results offer a novel route to the design and construction of ‘water-in-water' micro-droplet arrays with controllable spatial organization, programmable signalling pathways and higher order collective behaviour. Isolated droplets can be used as micro-reactors, yet it is challenging to operate them functionally in solution and observe chemical exchanges between droplets. Here, Tian et al. use an acoustic trap to assemble water-based micro-droplets into periodic arrays, spontaneously separated from solution media.
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DOI：
10.1016/j.jconrel.2014.06.028
发表时间：
2014-09-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
MacEwan SR;Chilkoti A
通讯作者：
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影响因子：
7.4
作者：
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影响因子：
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作者：
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DOI：
10.1098/rspa.2011.0269
发表时间：
2012-02-08
影响因子：
3.5
作者：
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通讯作者：
Cumming, D. R. S.
影响因子：
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作者：
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通讯作者：
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