Monodisperse selenium-substituted hydroxyapatite: Controllable synthesis and biocompatibility
Monodisperse selenium-substituted hydroxyapatite: Controllable synthesis and biocompatibility
复制标题
单分散硒取代羟基磷灰石：可控合成与生物相容性
DOI：
10.1016/j.msec.2016.12.106
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发表时间：
2017-04-01
影响因子：
7.9
通讯作者：
Hui, Junfeng
中科院分区：
文献类型：
--
作者：
Sun, Jianpeng;Zheng, Xiaoyan;Hui, Junfeng
Hydroxyapatite (HA) is the major inorganic component of natural bone tissue. As an essential trace element, selenium involves in antioxidation and anticancer of human body. So far, ion-doped hydroxyapatites (HAs) are widely investigated owing to their great applications in field of biomaterial, biological labeling. In this paper, series of monodisperse HA doped with SeO32- (SeHA) was successfully synthesized based on the liquid-solid-solution (LSS) strategy. The obtained samples were characterized by transmission electron microscopy (TEM), Xray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and energy-dispersive spectrometer (EDS). The results indicated that the SeO32- doping level of the Se/(P + Se) molar ratio of 0-0.4 can be requisitely controlled, and the morphology of SeHA nanoparticles varied from nanorods to nanoneedles with increasing Se/(P + Se) molar ratio. Significantly, the as-synthesized SeHA nanocrystals exhibit a low cytotoxicity for osteoblastic cells, showing exciting potentials for application in artificial scaffold materials inhibiting of tumor growth in bone. (C) 2016 Elsevier B.V. All rights reserved.
