Plastic Antibodies for Cosmetics: Molecularly Imprinted Polymers Scavenge Precursors of Malodors
Plastic Antibodies for Cosmetics: Molecularly Imprinted Polymers Scavenge Precursors of Malodors
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DOI：
10.1002/anie.201602076
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发表时间：
2016-05-17
影响因子：
16.6
通讯作者：
Bui, Bernadette Tse Sum
中科院分区：
文献类型：
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作者：
Nestora, Sofia;Merlier, Franck;Bui, Bernadette Tse Sum
分子印迹聚合物（MIPs）是能够特异性识别分子的合成抗体模拟物。有利地，它们更稳定，易于针对给定应用进行定制，并且比抗体更便宜。这些塑料抗体正在引起越来越多的兴趣，一个相对未开发的领域，他们可以发挥这些优势，特别是化妆品。在这里，我们提出了MIP作为化妆品的活性成分用于抑制体臭的用途。在皮肤化妆品配方中，MIP选择性地捕获恶臭化合物的前体，以及人体汗液中存在的其他分子的中间体。这些结果为制备在高度复杂的水环境中具有改进的选择性的新一代分子印迹聚合物铺平了道路，并且应该也适用于生物技术和生物医学领域。
Molecularly imprinted polymers (MIPs) are synthetic antibody mimics capable of specific molecular recognition. Advantageously, they are more stable, easy to tailor for a given application and less expensive than antibodies. These plastic antibodies are raising increasing interest and one relatively unexplored domain in which they could outplay these advantages particularly well is cosmetics. Here, we present the use of a MIP as an active ingredient of a cosmetic product, for suppressing body odors. In a dermo-cosmetic formulation, the MIP captures selectively the precursors of malodorous compounds, amidstamultitude of other molecules present in human sweat. These results pave the way to the fabrication of a novel generation of MIPs with improved selectivities in highly complex aqueous environments, and should be applicable to biotechnological and biomedical areas as well.