Establishment of a diazepam preference in human volunteers following a differential-conditioning history of placebo versus diazepam choice
Establishment of a diazepam preference in human volunteers following a differential-conditioning history of placebo versus diazepam choice
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DOI：
10.1037//1064-1297.10.2.77
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发表时间：
2002-05-01
影响因子：
2.3
通讯作者：
Johanson, CE
中科院分区：
文献类型：
--
作者：
Alessi, SM;Roll, JM;Johanson, CE
这项研究检验了是否可以通过调节程序来改变对药物（地西泮或安慰剂）的偏好。在第一阶段的前 4 个疗程中，6 名参与者在双盲条件下接受了 5 毫克地西泮或安慰剂。在第一阶段的剩余 5 次会议中，参与者选择了他们希望收到的药物。第二阶段的前 4 个疗程是第一阶段的复制，只不过参与者在服用药物后完成了一项可以赚钱的计算机任务。在第一阶段摄入他们喜欢的药物后，计算机任务的报酬最低，而在他们避免使用的药物后，计算机任务的报酬最高。在第 2 阶段的最后 5 次会议期间重新评估了偏好。其中 5 名参与者在第 1 阶段更喜欢红色安慰剂，但在第 2 阶段更喜欢地西泮。在这两个阶段中，对药物的主观反应也发生了变化。
This study examined whether preference for a drug (diazepam or placebo) could be switched using conditioning procedures. During the first 4 sessions of Phase 1, 6 participants received 5 mg of diazepam or placebo under double-blind conditions. During the remaining 5 sessions of Phase 1, participants selected the drug they wished to receive. The first 4 sessions of Phase 2 were a replication of Phase 1, except that following ingestion of the drug, participants completed a computer task for which they could earn money. Payment for the computer task was lowest following ingestion of the drug they preferred in Phase 1 and highest following the drug they had avoided. Preference was reassessed during the last 5 sessions of Phase 2. Five of the participants prefer-red placebo in Phase 1 but diazepam in Phase 2. Subjective responses to the drugs also changed across the 2 phases.