Genetic contribution to individual variation in binocular rivalry rate
Genetic contribution to individual variation in binocular rivalry rate
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DOI：
10.1073/pnas.0912149107
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发表时间：
2010-02-09
影响因子：
11.1
通讯作者：
Wright, Margaret J.
中科院分区：
文献类型：
--
作者：
Miller, Steven M.;Hansell, Narelle K.;Wright, Margaret J.
当冲突的图像出现在两只眼睛的相应位置时，就会发生双眼竞争。感知在图像之间以一个在个体内相对稳定的速率交替，但在个体之间变化很大。这种变化的决定因素尚不清楚。此外，在双相情感障碍（一种具有高遗传力的精神疾病）中也证明了缓慢的双眼竞争。因此，本研究检验了双眼竞争率的个体差异是否存在遗传因素。我们采用双胞胎方法，研究了基因相同的同卵 (MZ) 双胞胎（n = 128 对）和具有大约一半基因的异卵 (DZ) 双胞胎（n = 220 对）。 MZ 和 DZ 双胞胎双眼竞争率的相关性分别为 0.51 和 0.19。最拟合的遗传模型显示，52% 的双眼竞争率差异是由加性遗传因素造成的。相比之下，非共享环境影响占方差的 18%，其余归因于测量误差。因此，这项研究证明了遗传因素对双眼竞争率的个体差异有很大影响。这些结果支持了对双眼竞争的遗传和分子研究的大力追求，并进一步将缓慢的双眼竞争描述为双相情感障碍的内表型。
Binocular rivalry occurs when conflicting images are presented in corresponding locations of the two eyes. Perception alternates between the images at a rate that is relatively stable within individuals but that varies widely between individuals. The determinants of this variation are unknown. In addition, slow binocular rivalry has been demonstrated in bipolar disorder, a psychiatric condition with high heritability. The present study therefore examined whether there is a genetic contribution to individual variation in binocular rivalry rate. We employed the twin method and studied both monozygotic (MZ) twins (n = 128 pairs) who are genetically identical, and dizygotic (DZ) twins (n = 220 pairs) who share roughly half their genes. MZ and DZ twin correlations for binocular rivalry rate were 0.51 and 0.19, respectively. The best-fitting genetic model showed 52% of the variance in binocular rivalry rate was accounted for by additive genetic factors. In contrast, nonshared environmental influences accounted for 18% of the variance, with the remainder attributed to measurement error. This study therefore demonstrates a substantial genetic contribution to individual variation in binocular rivalry rate. The results support the vigorous pursuit of genetic and molecular studies of binocular rivalry and further characterization of slow binocular rivalry as an endophenotype for bipolar disorder.