Neuroanatomical substrates involved in true and false memories for face
Neuroanatomical substrates involved in true and false memories for face
复制标题
DOI：
10.1016/j.neuroimage.2012.04.044
复制
发表时间：
2012-08
期刊：
影响因子：
5.7
通讯作者：
T. Iidaka;T. Harada;J. Kawaguchi;N. Sadato
中科院分区：
文献类型：
--
作者：
T. Iidaka;T. Harada;J. Kawaguchi;N. Sadato
我们经常因为面部特征的相似性而把陌生人误认为熟悉的人。这种现象被称为错误记忆，主要是使用单词，图片和形状进行研究。以前关于错误记忆的神经影像学研究表明，真实和错误记忆都会触发内侧颞叶的类似激活，这表明它在两者中起着共同的作用。然而，迄今为止，还没有研究探讨面孔错误记忆的神经基础。在目前的fMRI研究中，我们采用了一个修改后的版本的标准错误记忆范式，使用变形图片的面孔，诱导错误记忆在MRI环境中。我们发现，杏仁核和眶皮层的活动与项目的熟悉程度有关。特别是，对“诱饵”项目的错误反应引起杏仁核的活动水平介于对“真实”项目的正确或不正确反应之间。这表明杏仁核在错误记忆中可能起作用。前扣带皮层中的一个特定区域参与了错误识别;该活动与反应类型的反应时间相关。这些结果表明，杏仁核参与确定项目的相关性，因此，模糊的诱惑项目的熟悉性和新奇性可能与杏仁核的活动减少。错误记忆中的前扣带回活动可能不仅是由增加的努力和运动需求引起的，也可能是由对诱饵项目的高级记忆加工引起的。
We often mistake an unknown person for a familiar person because of the similarities in facial features. This phenomenon, known as false memory, has been investigated mainly using words, pictures, and shapes. Previous neuroimaging studies on false memory have shown that both true and false memories trigger a similar activation in the medial temporal lobe, suggesting that it plays a common role in both. However, no study to date has investigated neural substrates of false memories for faces. In the present fMRI study, we applied a modified version of the standard false memory paradigm, using morphed pictures of faces, to induce false memory in an MRI environment. We found that activity in the amygdala and orbital cortices was associated with the degree of familiarity of items. In particular, false responses to “lure” items evoked a level of activity in the amygdala between that evoked for correct or incorrect responses to “true” items. This indicates a possible role of the amygdala in false memory. A specific region in the anterior cingulate cortex was involved in false recognition; the activity being correlated to reaction times for the response types. These results suggest that the amygdala is involved in determining the relevance of items; therefore, ambiguousness of lure items in terms of familiarity and novelty may be related to decreased activity in the amygdala. The anterior cingulate activity in false memory may be caused not only by increased effort and motor demand but also by higher mnemonic processing of lure items.