A Mobile-Based App (MyChoices) to Increase Uptake of HIV Testing and Pre-Exposure Prophylaxis by Young Men Who Have Sex With Men: Protocol for a Pilot Randomized Controlled Trial
A Mobile-Based App (MyChoices) to Increase Uptake of HIV Testing and Pre-Exposure Prophylaxis by Young Men Who Have Sex With Men: Protocol for a Pilot Randomized Controlled Trial
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DOI：
10.2196/10694
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发表时间：
2019-01-01
影响因子：
1.7
通讯作者：
Mayer, Kenneth H.
中科院分区：
文献类型：
--
作者：
Biello, Katie B.;Marrow, Elliot;Mayer, Kenneth H.
背景：在美国，男男性行为者（YMSM）中的艾滋病发病率增长最快。压倒性的证据表明，常规检测和扩大使用暴露前预防（PrEP）将大大减少艾滋病毒的人口负担;然而，这两种干预措施的吸收在年轻人中是次优的。YMSM对移动的手机应用程序的使用无处不在，可能为公共卫生干预提供独特的机会。MyChoices是一个理论驱动的应用程序，以增加艾滋病毒检测和PrEP的吸收。它是由一个跨学科的团队开发的反馈的基础上，从一个不同的样本YMSM.Objective：本文的目的是描述的协议，细化，β测试，和试点随机对照试验（RCT），以检查的可接受性和可行性的MyChoices app.Methods：这个3阶段的研究包括4个剧院测试组的应用程序细化，共约30 YMSM;在2个月的时间内，对大约15名YMSM进行beta测试，包括定量评估和离职面谈;以及对60名YMSM进行试点RCT。该试点将评估MyChoices应用程序与仅转诊相比在增加艾滋病毒检测和PrEP吸收方面的可行性，可接受性和初步疗效。所有参与者将在马萨诸塞州波士顿和纽约州布朗克斯的iTech临床研究中心招募。结果：应用程序改进正在进行中。试点RCT的招募工作于2018年10月开始。结论：MyChoices是第一个专门为YMSM设计的综合性、理论驱动的HIV预防应用程序之一。如果MyChoices在该先导性RCT中证明了可接受性和可行性，则计划在iTech中进行一项多城市、3组随机对照疗效试验，比较该应用程序和另一种针对年轻人的优化应用程序（LYNX）与标准治疗。如果被证明是有效的，该应用程序将是可扩展的，能够覆盖美国各地的YMSM，并在地理上个性化，应用程序内容与当地的预防和检测活动相结合。
Background: HIV incidence is growing most rapidly in the United States among young men who have sex with men (YMSM). Overwhelming evidence demonstrates that routine testing and expanded use of pre-exposure prophylaxis (PrEP) would dramatically reduce the population burden of HIV; however, uptake of both interventions is suboptimal among young adults. The use of mobile phone apps by YMSM is ubiquitous and may offer unique opportunities for public health interventions. MyChoices is a theory-driven app to increase HIV testing and PrEP uptake. It was developed by an interdisciplinary team based on feedback from a diverse sample of YMSM.Objective: The aim of this paper is to describe the protocol for the refinement, beta testing, and pilot randomized controlled trial (RCT) to examine the acceptability and feasibility of the MyChoices app.Methods: This 3-phase study includes 4 theater testing groups for app refinement with a total of approximately 30 YMSM; for beta testing, including quantitative assessments and exit interviews, with approximately 15 YMSM over a 2-month period; and for a pilot RCT with 60 YMSM. The pilot will assess feasibility, acceptability, and preliminary efficacy of the MyChoices app, compared with referrals only, in increasing HIV testing and PrEP uptake. All participants will be recruited at iTech clinical research sites in Boston, MA, and Bronx, NY.Results: App refinement is underway. Enrollment for the pilot RCT began in October 2018.Conclusions: MyChoices is one of the first comprehensive, theory-driven HIV prevention apps designed specifically for YMSM. If MyChoices demonstrates acceptability and feasibility in this pilot RCT, a multicity, 3-arm randomized controlled efficacy trial of this app and another youth-optimized app (LYNX) versus standard of care is planned within iTech. If shown to be efficacious, the app will be scalable, with the ability to reach YMSM across the United States as well as be geographically individualized, with app content integrated with local prevention and testing activities.