Evaluation of the Cortical Silent Period of the Laryngeal Motor Cortex in Healthy Individuals.
Evaluation of the Cortical Silent Period of the Laryngeal Motor Cortex in Healthy Individuals.
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DOI：
10.3389/fnins.2017.00088
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发表时间：
2017
影响因子：
4.3
通讯作者：
Kimberley TJ
中科院分区：
文献类型：
--
作者：
Chen M;Summers RL;Goding GS;Samargia S;Ludlow CL;Prudente CN;Kimberley TJ
目的：本研究旨在利用经颅磁刺激（TMS）测量双侧甲杓肌（TA）的喉运动皮质（LMC）的皮质沉默期（cSP）。研究方法：在11名健康受试者中，使用细丝肌电图（EMG）记录双侧TA肌肉对单脉冲TMS传递到两个半球的LMC的反应。收集迷走神经离开颅骨的乳突上对刺激的外周反应，以通过比较lavelet来验证皮质刺激反应的中枢起源。结果如下：cSP持续时间范围为41.7 - 66.4 ms。外周诱发运动诱发电位（MEP）峰值比皮层反应早5 - 9 ms（两侧TA：p <0.0001），无静默期。对于外周和皮质测量，右侧TA MEP潜伏期均早于左侧TA反应（p ≤ 0.0001）。结论：这些结果表明，在健康志愿者的发声过程中的喉内肌反应的基础上测量LMC的cSP的可行性。意义：该技术可用于研究影响TA肌肉的神经系统疾病的病理生理学，如痉挛性发声障碍。此外，该方法可应用于使用表面电极无法接近的头部和颈部的其他肌肉。
Objective: This work aimed to evaluate the cortical silent period (cSP) of the laryngeal motor cortex (LMC) using the bilateral thyroarytenoid (TA) muscles with transcranial magnetic stimulation (TMS). Methods: In 11 healthy participants, fine-wire electromyography (EMG) was used to record bilateral TA muscle responses to single pulse TMS delivered to the LMC in both hemispheres. Peripheral responses to stimulation over the mastoid, where the vagus nerve exits the skull, were collected to verify the central origin of the cortical stimulation responses by comparing the latencies. Results: The cSP duration ranged from 41.7 to 66.4 ms. The peripherally evoked motor-evoked potential (MEP) peak occurred 5–9 ms earlier than the cortical responses (for both sides of TAs: p < 0.0001) with no silent period. The right TA MEP latencies were earlier than the left TA responses for both peripheral and cortical measures (p ≤ 0.0001). Conclusion: These findings demonstrate the feasibility of measuring cSP of LMC based on intrinsic laryngeal muscles responses during vocalization in healthy volunteers. Significance: The technique could be used to study the pathophysiology of neurological disorders that affect TA muscles, such as spasmodic dysphonia. Further, the methodology has application to other muscles of the head and neck not accessible using surface electrodes.