Topochemical polymerization in supramolecular polymers of oligopeptide-functionalized diacetylenes
Topochemical polymerization in supramolecular polymers of oligopeptide-functionalized diacetylenes
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DOI：
10.1002/anie.200600610
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Frauenrath, Holger
中科院分区：
文献类型：
--
作者：
Jahnke, Eike;Lieberwirth, Ingo;Frauenrath, Holger
针对光电子学和生物科学界面应用的新一代合成聚合物必须“说生物材料的语言”并模仿其功能。它们必须提供与生物系统在分子水平上相互作用的化学功能，并表现出形成分层结构的类似能力。[1]超分子自组装是制备具有纳米结构特征材料的有力工具。[2]近年来，寡肽通过聚集和形成β折叠的自组装受到越来越多的关注。这种方法是由神经退行性疾病领域的研究活动推动的。[3]值得注意的例子包括基于淀粉样蛋白的寡肽的自组装，[4]从合成寡肽形成有机凝胶并将其沉积在表面上，[5]肽模拟物分子的聚集[6]和PEG缀合物，[7]受蜘蛛丝启发的多嵌段共聚物，[8]以及在金纳米线制造中使用自组装寡肽。[9]聚二乙炔是一种光电活性材料。只要单体的所需结晶顺序确定，二乙炔的局部化学聚合就有可能。[10]例如，它们已经在二炔酸及其盐的自组装单层或多层中进行[11]，以及在表面上的自组装单层中沿沿着1D层状结构进行。[12]含二乙炔
New generations of synthetic polymers targeting applications at the interface of optoelectronics and the biosciences must “speak the language” of biomaterials and mimic their functioning. They must provide the chemical functionality to interact with biological systems on the molecular level and exhibit a similar ability to form hierarchical structures.[1] Supramolecular self-assembly has proven to be a powerful tool for the preparation of materials with structural features on the nanometer scale.[2] Recently, the self-assembly of oligopeptides through aggregation and formation of β sheets has received increasing attention. This approach has been prompted by research activities in the field of neurodegenerative diseases.[3] Notable examples include the self-assembly of oligopeptides based on amyloids,[4] the formation of organogels from synthetic oligopeptides and their deposition on surfaces,[5] the aggregation of peptidomimetic molecules [6] and PEG conjugates,[7] multiblock copolymers inspired by spider silk,[8] as well as the use of self-assembled oligopeptides in the manufacture of gold nanowires.[9] Poly (diacetylene) s are optoelectronically active materials. Topochemical polymerizations of diacetylenes are possible whenever the required crystalline order of the monomers is established.[10] They have, for example, been performed in self-assembled mono-or multilayers of diynoic acids and their salts [11] as well as along 1D lamellar structures in selfassembled monolayers on surfaces.[12] Diacetylene-containing