Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis
Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis
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DOI：
10.1042/bst0350207
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发表时间：
2007-04-01
影响因子：
3.9
通讯作者：
Eickholt, B. J.
中科院分区：
文献类型：
--
作者：
Cosker, K. E.;Eickholt, B. J.
神经元形态的建立对于神经系统的形成至关重要。一般来说，神经元会经历一个发育过程，在此期间它们未成熟的突起被特化为一个轴突和若干树突。轴突和树突的延伸对于建立适当的连接至关重要。大量研究表明，PI3K（磷脂酰肌醇3 - 激酶）信号通路在导致神经回路形成的各种事件中起着关键作用。在这篇综述中，我们将特别关注PI3K以及控制轴突特化和伸长建立的下游信号级联的功能。
The establishment of neuronal morphology is essential for the formation of the nervous system. In general, neurons undergo a developmental programme during which their immature processes are specified into one axon and several dendrites. Extension of axons and dendrites is then critical for the establishment of appropriate connectivity. A body of work implicates the PI3K (phosphoinositide 3-kinase) signalling pathway to be crucial during the various events leading to the formation of neuronal circuit. In this review, we will focus specifically on the function of PI3K and downstream signalling cascades that control the establishment of axonal specification and elongation.