IS CENTRIOLE BOUND TO NUCLEAR-MEMBRANE
IS CENTRIOLE BOUND TO NUCLEAR-MEMBRANE
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DOI：
10.1038/270080a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
BORNENS, M
中科院分区：
文献类型：
--
作者：
BORNENS, M
在分裂间期，中心粒在所谓的细胞中心内的核附近的持续存在似乎是大多数动物细胞的一个普遍特征。已经提出了细胞核和细胞中心之间的关联，并在某些细胞类型中清楚地显示了这一点1，2。Lettreet等人3提出了一个涉及染色体、纺锤纤维和中心粒的永久系统，而Aronson 4证明了海胆Lytechinus variegatus两细胞阶段的细胞核和中心之间存在一个对秋水仙胺敏感的移动的系统。我们在这里表明，有一个物理协会之间的中心粒和细胞核在大鼠肝细胞，抵抗冷处理，细胞分裂和核隔离。当从分离的细胞核制备核膜时，中心粒和核膜之间的结合得以维持。
THE persistence of the centriole during interphase near the nucleus within the so-called cell centre seems to be a general feature of most animal cells. An association between the nucleus and the cell centre has been proposed and has been clearly shown in some cell types1,2. A permanent system involving chromosomes, spindle fibres and centrioles has been suggested by Lettreet al.3, and Aronson4has demonstrated the existence of a Colcemid-sensitive mobile system between the nucleus and a centre at the two-cell stage in the sea urchinLytechinus variegatus. We show here that there is a physical association between the centriole and the nucleus in the rat liver cell which resists cold treatment, cell disruption and nuclear isolation. When nuclear envelopes are prepared from isolated nuclei, the association between the centriole and the nuclear envelope is maintained.