ACJ6 - A GENE AFFECTING OLFACTORY PHYSIOLOGY AND BEHAVIOR IN DROSOPHILA
ACJ6 - A GENE AFFECTING OLFACTORY PHYSIOLOGY AND BEHAVIOR IN DROSOPHILA
复制标题
DOI：
10.1073/pnas.88.12.5467
复制
发表时间：
1991-06-01
影响因子：
11.1
通讯作者：
CARLSON, J
中科院分区：
文献类型：
--
作者：
AYER, RK;CARLSON, J
影响嗅觉行为的突变为果蝇嗅觉的分子研究提供了材料。利用触角电图（EAG），触角生理的措施，我们发现了一个成年触角缺陷的嗅觉行为突变异常化学感觉跳跃6（acj 6）。的acj 6 EAG缺陷被映射到一个单一的基因座和相同的突变被发现是负责EAG振幅和减少行为反应的减少，如果减少触角对气味的反应是负责异常的化学感觉行为的突变体。ACJ 6幼虫的嗅觉行为也是异常的;突变似乎改变了两个发育阶段嗅觉所必需的细胞过程。acj 6突变表现出特异性，即视觉系统功能在幼虫和成虫中表现正常。这些实验证明acj 6基因编码嗅觉信号传导所需的产物。
Mutations affecting olfactory behavior provide material for use in molecular studies of olfaction in Drosophila melanogaster. Using the electroantennogram (EAG), a measure of antennal physiology, we have found an adult antennal defect in the olfactory behavioral mutant abnormal chemosensory jump 6 (acj6). The acj6 EAG defect was mapped to a single locus and the same mutation was found to be responsible for both reduction in EAG amplitude and diminished behavioral response, as if reduced antennal responsiveness to odorant is responsible for abnormal chemosensory behavior in the mutant. acj6 larval olfactory behavior is also abnormal; the mutation seems to alter cellular processes necessary for olfaction at both developmental stages. The acj6 mutation exhibits specificity in that visual system function appears normal in larvae and adults. These experiments provide evidence that the acj6 gene encodes a product required for olfactory signal transduction.