Association of serum irisin with metabolic syndrome in obese Chinese adults.
Association of serum irisin with metabolic syndrome in obese Chinese adults.
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DOI：
10.1371/journal.pone.0094235
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Yan B;Shi X;Zhang H;Pan L;Ma Z;Liu S;Liu Y;Li X;Yang S;Li Z
Irisin是最近发现的一种新型肌因子，它驱动白色脂肪组织的棕色脂肪样转化，并已被提出介导运动对代谢的有益作用。2型糖尿病患者循环中的鸢尾素显着减少;然而，没有证据表明它与代谢综合征（MetS）有关，肥胖和肌肉质量对循环中的鸢尾素的影响一直存在争议。收集了1,115名社区生活的中国中心性肥胖成年人的社会人口学、生活方式、临床特征和血清鸢尾素的横断面数据。采用多变量logistic回归分析血清鸢尾素与MetS（向心性肥胖加上以下四个因素中的任何两个（血压（BP）升高、空腹血糖（FPG）升高、甘油三酯（TG）升高和HDL胆固醇降低））和MetS的每个组分的关联。在平均年龄为53.2（±7.2）岁的1，115名肥胖中国成年人中，MetS和FPG升高受试者的血清鸢尾素水平（对数转换）显著低于其对照组（分别为p=0.034和0.041）。 校正潜在混杂因素后，血清鸢尾素与MetS风险降低和FPG升高显著相关，对数转换鸢尾素标准差的比值比（OR）（95%CI）分别为0.796（0.505-0.959，p = 0.027）和0.873（0.764-0.998，p = 0.046）。 鸢尾素与血压升高、甘油三酯升高和HDL降低的相关性无统计学意义（OR（95% CI）分别为：0.733（0.454-1.182，p = 0.202）、0.954（0.838-1.086，p = 0.478）和1.130（0.980-1.302，p = 0.092））。 逐步多元线性回归分析显示空腹胰岛素、HbA 1c和白蛋白/球蛋白比值与血清irisin水平呈负相关，具有统计学意义（所有p值均<0.05），腰围与血清irisin呈负相关，具有边缘统计学意义（p = 0.055）。 这些结果表明，鸢尾素可能在胰岛素抵抗和代谢综合征中发挥重要作用，并应在未来的前瞻性研究中予以证实。
Irisin, a recently identified novel myokine, drives brown-fat-like conversion of white adipose tissues and has been proposed to mediate beneficial effects of exercise on metabolism. Circulating irisin was significantly reduced in type 2 diabetes patients; however, no evidence is available about its association with metabolic syndrome (MetS) and effects of adiposity and muscle mass on circulating irisin have been controversial. Cross-sectional data on socio-demographic, lifestyle, clinical characteristics and serum irisin were collected for 1,115 community-living Chinese adults with central obesity. Associations of serum irisin with MetS (central obesity plus any two of the following four factors (raised blood pressure (BP), raised fasting plasma glucose (FPG), raised triglyceride (TG), and reduced HDL cholesterol) and each component of MetS were analyzed using multivariable logistic regression. Among the 1,115 obese Chinese adults with a mean age of 53.2(±7.2) years, serum irisin levels (log-transformed) were significantly reduced in subjects with MetS and raised FPG than their control groups (p = 0.034 and 0.041, respectively). After adjustment for potential confounders, serum irisin was significantly associated with reduced risks of MetS and raised FPG, with odds ratios (ORs) (95% CI) per standard deviation of log-transformed irisin of 0.796 (0.505–0.959, p = 0.027) and 0.873 (0.764–0.998, p = 0.046), respectively. Associations of irisin with raised BP, raised TG and reduced HDL were not statistically significant ((ORs) (95% CI): 0.733(0.454–1.182, p = 0.202), 0.954(0.838–1.086, p = 0.478) and 1.130(0.980–1.302, p = 0.092), respectively). Stepwise multivariable linear regression analysis showed that fasting insulin, HbA1c and albumin/globulin ratio were negatively associated with serum irisin level with statistical significance (all p-values <0.05) and waist circumference was negatively associated with serum risin with marginally statistical significance (p = 0.055). These results imply that irisin may play an important role in insulin resistance and MetS and should be confirmed in future prospective studies.