Bell's palsy and parenteral inactivated influenza vaccine
Bell's palsy and parenteral inactivated influenza vaccine
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DOI：
10.4161/hv.2790
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发表时间：
2006-05-01
期刊：
影响因子：
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通讯作者：
Miller, Elizabeth
中科院分区：
文献类型：
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作者：
Stowe, Julia;Andrews, Nick;Miller, Elizabeth
2004年瑞士发表的一项研究表明，鼻腔注射灭活流感疫苗会增加贝尔氏麻痹的风险，这引起了人们对注射灭活流感疫苗后贝尔氏麻痹风险可能增加的担忧。当检查来自美国和英国被动报告系统的数据时，有一些证据表明注射注射疫苗后报告增加。因此，利用全科医学研究数据库（GPRD）进行了一项基于人群的大型研究，以检验在注射灭活流感疫苗后三个月内贝尔氏麻痹风险增加的假设。接种肺炎球菌疫苗后同一时期的风险也进行了评估，并分为三个年龄组(
Concern about a possible increased risk of Bell's palsy after parenteral inactivated influenza vaccine was raised following the publication in 2004 of a Swiss study in which there was an increased risk following the nasal inactivated formulation of the vaccine. When data from passive reporting systems in the United States and the United Kingdom were examined there was some evidence of increased reporting following the parenteral vaccine. A large population based study using the General Practice Research Database (GPRD) was therefore performed to test the hypothesis that there was an increased risk of Bell's palsy in the three months following parenteral inactivated influenza vaccine. The risk was also assessed for the same period following pneumococcal vaccine and was stratified into three age groups (