Selection on Optimal Haploid Value Increases Genetic Gain and Preserves More Genetic Diversity Relative to Genomic Selection
Selection on Optimal Haploid Value Increases Genetic Gain and Preserves More Genetic Diversity Relative to Genomic Selection
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DOI：
10.1534/genetics.115.178038
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发表时间：
2015-08-01
期刊：
影响因子：
3.3
通讯作者：
Hayes, Ben J.
中科院分区：
文献类型：
--
作者：
Daetwyler, Hans D.;Hayden, Matthew J.;Hayes, Ben J.
在植物育种计划中，通常产生双单倍体并进行表型选择以加速育种周期。利用表型和基因型两者的基因组选择已被证明通过在新种质的表型表征之前或不进行表型表征的情况下预测表现来进一步改善遗传增益。存在将联合收割机基因组预测方法与双单倍体的产生相结合的额外机会。在这里，我们提出了一个扩展的基因组选择，最佳的单倍体价值（OHV）的选择，它预测最好的加倍单倍体，可以产生从分离的植物。该方法将选择集中在单倍型上，并朝着产生精英固定系的最终目标优化育种程序。我们使用计算机模拟严格测试了OHV选择育种程序，并表明它比基因组选择的遗传增益高出0.6个标准差。与此同时，OHV选择在种群中保留了比基因组选择大得多的遗传多样性，这对于在育种种群中实现长期遗传增益很重要。
Doubled haploids are routinely created and phenotypically selected in plant breeding programs to accelerate the breeding cycle. Genomic selection, which makes use of both phenotypes and genotypes, has been shown to further improve genetic gain through prediction of performance before or without phenotypic characterization of novel germplasm. Additional opportunities exist to combine genomic prediction methods with the creation of doubled haploids. Here we propose an extension to genomic selection, optimal haploid value (OHV) selection, which predicts the best doubled haploid that can be produced from a segregating plant. This method focuses selection on the haplotype and optimizes the breeding program toward its end goal of generating an elite fixed line. We rigorously tested OHV selection breeding programs, using computer simulation, and show that it results in up to 0.6 standard deviations more genetic gain than genomic selection. At the same time, OHV selection preserved a substantially greater amount of genetic diversity in the population than genomic selection, which is important to achieve long-term genetic gain in breeding populations.