Physical Activity to Reduce Fatigue in Rheumatoid Arthritis: A Randomized Controlled Trial
Physical Activity to Reduce Fatigue in Rheumatoid Arthritis: A Randomized Controlled Trial
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DOI：
10.1002/acr.23230
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发表时间：
2018-01-01
影响因子：
4.7
通讯作者：
Trupin, Laura
中科院分区：
文献类型：
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作者：
Katz, Patricia;Margaretten, Mary;Trupin, Laura
类风湿性关节炎（RA）的有效治疗方法是有限的。我们测试的影响，以计步器为基础的干预增加体力活动和减少疲劳的个人RA。MethodsParticipants完成基线问卷调查，有1周的活动监测，随机对照（教育[EDUC]），计步器和步监测日记（PED），或计步器和日记加步骤目标（PED+）组，并随访21周。在第10周，通过电话向所有参与者进行问卷调查。在最后一周，所有参与者再次进行1周的活动监测。主要结局是平均每周步数和疲劳（患者报告结局测量信息系统7项问卷）从基线至第21周的变化。次要结果是自我报告的疾病活动，身体功能，疼痛干扰和抑郁症状。使用线性混合模型测试步骤的变化。疲劳的变化进行了测试与重复测量模型，包括基线，第10周，和第21周scores.ResultsA共96个人参加。8人没有完成21周的评估。两个干预组均显著增加了步数（PED组为+1，441 [P = 0.004]，PED+组为+1，656 [P = 0.001]），EDUC组减少了步数（-747 [P = 0.14]）（组与时间相互作用P = 0.0025）。组间疲劳变化无显著差异（相互作用P = 0.21）。EDUC、PED和PED+组从基线至第21周的疲劳评分平均变化分别为-1.6（组内P = 0.26）、-3.2（P = 0.02）和-4.8（P = 0.0002）。功能和自我报告的疾病活动也改善了PED和PED+ groups.ConclusionProvision的计步器，与和不提供步骤的目标，是成功的增加活动水平和减少疲劳，在这个样本的个人与RA。
ObjectiveEffective treatments for rheumatoid arthritis (RA) fatigue are limited. We tested the effect of a pedometer-based intervention on increasing physical activity and decreasing fatigue among individuals with RA.MethodsParticipants completed baseline questionnaires; had 1 week of activity monitoring; were randomized to control (education [EDUC]), pedometer and step-monitoring diary (PED), or pedometer and diary plus step targets (PED+) groups, and were followed for 21 weeks. At week 10, questionnaires were administered by phone to all participants. During the final week, all participants again had 1 week of activity monitoring. Primary outcomes were changes in average weekly steps and fatigue (Patient-Reported Outcomes Measurement Information System 7-item questionnaire) from baseline to week 21. Secondary outcomes were self-reported disease activity, physical function, pain interference, and depressive symptoms. Changes in steps were tested using a linear mixed model. Changes in fatigue were tested with repeated-measures models, including baseline, week-10, and week-21 scores.ResultsA total of 96 individuals participated. Eight did not complete the 21-week assessments. Both intervention groups significantly increased steps (+1,441 [P = 0.004] for PED and +1,656 [P = 0.001] for PED+), and the EDUC group decreased steps (-747 [P = 0.14]) (group-by-time interaction P = 0.0025). Between-group changes in fatigue were not significantly different (interaction P = 0.21). Mean changes in fatigue scores from baseline to week 21 were -1.6 (with-group P = 0.26), -3.2 (P = 0.02), and -4.8 (P = 0.0002) for EDUC, PED, and PED+ groups, respectively. Function and self-reported disease activity also improved in the PED and PED+ groups.ConclusionProvision of pedometers, with and without providing step targets, was successful in increasing activity levels and decreasing fatigue in this sample of individuals with RA.