Autoantibodies and SLE-the threshold for disease
Autoantibodies and SLE-the threshold for disease
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DOI：
10.1038/nrrheum.2013.184
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发表时间：
2014-03-01
影响因子：
33.7
通讯作者：
Karp, David R.
中科院分区：
文献类型：
--
作者：
Olsen, Nancy J.;Karp, David R.
在看似健康的个体中，自身抗体的存在已经越来越被认识到。尽管其中一些人处于疾病的临床前阶段，如系统性红斑狼疮(SLE)，但许多人不会发展为SLE或任何其他自身免疫性疾病。事实上，自身反应性在人群中的高度流行表明，自身抗体是健康免疫反应的一部分，其他数据清楚地表明，一些自身抗体具有重要的免疫调节功能。这些观察留下了良性自身免疫何时以及如何发展为疾病的悬而未决的问题。如果可以预测从临床前自身免疫到SLE等临床疾病的转变，那么早期并因此可能进行更有效的干预是可能的，治疗甚至可能成为现实。此外，增加对自身抗体控制机制的了解，可以确定流产或预防疾病转化的新方法。在这篇文章中，我们总结了目前关于表面上健康的个体中存在SLE相关抗体的发现，并就这些发现可能告诉我们自身抗体在疾病发展中的作用提供了我们的观点。
The presence of autoantibodies in apparently healthy individuals has been increasingly recognized. Although some of these individuals are in preclinical stages of a disease such as systemic lupus erythematosus (SLE), many will not develop SLE or any other autoimmune disorder. The high prevalence of autoreactivity in the population in fact suggests that autoantibodies are expressed as part of a healthy immune response, and other data have clearly shown that some autoantibodies have important immune regulatory functions. These observations leave open questions regarding when and how benign autoimmunity develops into disease. If the transition from preclinical autoimmunity to a clinical disorder such as SLE could be predicted, early and thus potentially more effective intervention might be possible and cures might even become a reality. Furthermore, increased understanding of mechanisms by which autoantibodies are kept in check can identify new approaches to aborting or preventing disease transformations. In this article, we summarize the current findings regarding the presence of SLE-associated antibodies in apparently healthy individuals, and provide our opinions on what such discoveries might tell us about the roles of autoantibodies in the development of disease.