European mitochondrial DNA haplogroups and liver fibrosis in HIV and hepatitis C virus coinfected patients
European mitochondrial DNA haplogroups and liver fibrosis in HIV and hepatitis C virus coinfected patients
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DOI：
10.1097/qad.0b013e328349820f
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发表时间：
2011-08-24
期刊：
影响因子：
3.8
通讯作者：
Resino, Salvador
中科院分区：
文献类型：
--
作者：
Garcia-Alvarez, Monica;Guzman-Fulgencio, Maria;Resino, Salvador
背景：HIV 感染、丙型肝炎病毒 (HCV) 肝病和线粒体 DNA (mtDNA) 多态性是三个可能相互关联的因素，可能与肝病的进展相关。本研究的目的是调查 mtDNA 单倍群是否对 HIV/HCV 合并感染患者的肝纤维化进展有影响。 方法：我们对 231 名通过 Sequenom 的 MassARRAY 平台（美国加利福尼亚州圣地亚哥）进行基因分型的患者进行了横断面研究。根据METAVIR评分评估肝纤维化程度。在每位患者中，纤维化进展率 (FPR) 的计算方法是将纤维化阶段 (0-4) 除以估计的 HCV 感染持续时间（以年为单位）。结果：簇或主要单倍群 HV 与晚期纤维化的比值比 (OR) 降低显着相关 [OR 0.35，95% 置信区间 (CI) 0.16-0.77，P = 0.009]、肝硬化 (OR 0.16，95% CI 0.04-0.60，P = 0.007），或高 FPR（OR 0.43，95% CI 0.21-0.84，P = 0.015）。在主要单倍群 HV 中，单倍群 H 与无晚期纤维化（OR 0.40，95% CI 0.18-0.91，P = 0.029）、肝硬化（OR 0.14，95% CI 0.03-0.67，P = 0.014）或高 FPR（OR 0.47，95% CI）显着相关。 0.23-0.95，P = 0.035）。我们还在密切相关的主要单倍群 U 中发现与肝硬化几率增加显着相关（OR 5.25，95% CI 1.76-15.64，P = 0.003）。结论：mtDNA 单倍群 HV 和 H 与较慢的纤维化进展相关，而单倍群 U 与 HIV/HCV 共感染患者的较快纤维化进展相关。这些数据表明mtDNA单倍群可能在HCV感染期间的肝纤维发生中发挥重要作用。 (C) 2011 年威科健康 |利平科特·威廉姆斯·威尔金斯
Background: HIV infection, hepatitis C virus (HCV) liver disease, and mitochondrial DNA (mtDNA) polymorphisms are three possibly interrelated factors that might be associated with progression of liver disease. The aim of this study was to investigate whether mtDNA haplogroups had any influence on liver fibrosis progression in HIV/HCV coinfected patients.Methods: We carried out a cross-sectional study in 231 patients who were genotyped via Sequenom's MassARRAY platform (San Diego, California, USA). Liver fibrosis was estimated based on the METAVIR score. In each patient, fibrosis progression rate (FPR) was calculated by dividing the fibrosis stage (0-4) by the estimated duration of HCV infection in years.Results: The cluster or major haplogroup HV was significantly associated with reduced odds ratios (OR) for advanced fibrosis [OR 0.35, 95% confidence interval (CI) 0.16-0.77, P = 0.009], cirrhosis (OR 0.16, 95% CI 0.04-0.60, P = 0.007), or high FPR (OR 0.43, 95% CI 0.21-0.84, P = 0.015). Within the major haplogroup HV, haplogroup H was significantly associated with an absence of advanced fibrosis (OR 0.40, 95% CI 0.18-0.91, P = 0.029), cirrhosis (OR 0.14, 95% CI 0.03-0.67, P = 0.014), or high FPR (OR 0.47, 95% CI 0.23-0.95, P = 0.035). We also found a significant association with increased odds of cirrhosis (OR 5.25, 95% CI 1.76-15.64, P = 0.003) in the closely related major haplogroup U.Conclusion: The mtDNA haplogroups HV and H were associated with slower fibrosis progression, and the haplogroup U was associated with faster fibrosis progression in HIV/HCV coinfected patients. These data suggest that mtDNA haplogroup may play a significant role in liver fibrogenesis during HCV infection. (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins